Variations in response of human brain tumors to BCNU in vitro.
Variations in response of human brain tumors to BCNU in vitro.
复制标题
人脑肿瘤体外对 BCNU 反应的变化。
作者：
P. Kornblith;P. E. Szypko
使用微量滴定法研究 24 个培养的人星形细胞瘤对化疗剂 1,3-双(2-氯乙基)-1 亚硝基脲 (BCNU) 的敏感性。睾丸肿瘤细胞系源自过去24个月内接受术后化疗的患者。在与最大体内治疗剂量水平相当的剂量水平下，测试的 24 个细胞系中有 18 个显示出对该药物的显着反应。如果体外反应最终可以与临床反应相关联，那么这种微量滴定测定可以帮助为规划更具体的化疗治疗奠定基础。
A microtiter assay was used to study the sensitivity of 24 cultured human astrocytomas to the chemotherapeutic agent 1,3-bis(2-chloroethyl)-1 nitrosourea (BCNU). The tumor cell lines testes originated from patients who were being treated with post-operative chemotherapy within the past 24 months. At a dose level comparable to the maximum in vivo therapeutic dose level, 18 of the 24 cell lines tested showed a significant response to the drug. If in vitro response can eventually be correlated with clinical response, this microtiter assay could help to form a basis for planning more specific chemotherapeutic treatment.