Circulating levels of inhibin A, inhibin B and activin A in normal and intrauterine growth restricted (IUGR) fetuses
Circulating levels of inhibin A, inhibin B and activin A in normal and intrauterine growth restricted (IUGR) fetuses
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DOI：
10.1016/j.ejogrb.2004.02.030
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发表时间：
2004-11-10
影响因子：
2.6
通讯作者：
Beck-Peccoz, P
中科院分区：
文献类型：
--
作者：
Morpurgo, PS;Cetin, I;Beck-Peccoz, P
目的：探讨正常和病理胎儿血中β-氨基丁酸酯A、β-氨基丁酸酯B和激活素A水平与性别、胎龄和促性腺激素的关系。研究设计：该研究包括31例正常胎儿和12例胎龄20 - 40周的宫内生长受限（IUGR）胎儿。结果：在正常人和正常人中，白细胞介素A和激活素A水平无性别差异。男性抑制素B水平显著高于女性（P <0.05）。在IUGR组中发现具有最高水平的活化素A和B的胎儿，其也显示活化素A水平显著高于正常。未观察到促性腺激素A、促性腺激素B、激活素A与两种促性腺激素之间的相关性。结论：胎儿宫内生活期间，血浆中的β-半乳糖苷酶A、β-半乳糖苷酶B和激活素A在男性和女性均存在。不同性别模式的Escherubin B表明Escherubin B可能有助于至少在男性中评估下丘脑-垂体-性腺设定点。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Objective: To evaluate the relationships between circulating levels of inhibin A, inhibin B and activin A, and sex, gestational age and gonadotropins in normal and pathological fetuses. Study design: The study included 31 normal fetuses and 12 affected with intrauterine growth restriction (IUGR) of gestational age ranging 20-40 weeks. Results: No gender difference in inhibin A and activin A levels were observed. Inhibin B levels were significantly higher in males than in females (P < 0.05). Fetuses with the highest levels of inhibin A and B were found in the IUGR group that also showed activin A levels significantly higher than normal. No correlations were observed between inhibin A, inhibin B, activin A and both gonadotropins. Conclusion: Plasma inhibin A, inhibin B and activin A are detectable in both genders during intrauterine life. The different gender pattern of inhibin B suggests that inhibin B may contribute to the assessment of the hypothalamic-pituitary-gonadal set-point at least in males. (C) 2004 Elsevier Ireland Ltd. All rights reserved.