In vitro study of the deployment performance of 3D printed stents in the diseased artery with the lipid arterial plaques
In vitro study of the deployment performance of 3D printed stents in the diseased artery with the lipid arterial plaques
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DOI：
10.1016/j.prostr.2022.12.077
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
M. Abdulsalam;J. Feng;R. Garrard;M. Attallah;F. Serracino-Inglott;L. Zhao
中科院分区：
文献类型：
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作者：
M. Abdulsalam;J. Feng;R. Garrard;M. Attallah;F. Serracino-Inglott;L. Zhao
动脉粥样硬化斑块是一种动脉疾病，它积聚在动脉壁中，可以通过斑块的成分来识别。动脉粥样硬化导致动脉管腔狭窄或闭塞，从而导致心血管事件。经皮（锁孔）血管内支架植入术因其微创性和低并发症发生率而成为最常见的血运重建方法。大多数由激光机器制造的支架具有均匀的几何形状，这对于治疗具有病变特异性的病变动脉并不理想。此外，动脉斑块成分对支架性能的影响尚未得到充分研究。在本研究中，研究了由316 L不锈钢制成并通过增材制造（AM）技术制造的不同设计支架的展开性能。进行体外实验以测试在55%狭窄下动脉粥样硬化斑块组成对商业和AM制造的支架的影响。手动制备两种人工斑块（脂质和钙化），并使用无侧限压缩试验进行机械试验。使用两种类型的支架（印刷支架和市售支架）治疗患病的人工动脉，并在施加支架充气压力时同时收集压力和直径的数据。结果表明，人工脂质斑块的力学性能与临床观察到的真实的脂质斑块非常相似。从这两种类型支架的展开性能试验中观察到，随着球囊内部压力的增加，当压力高于4 atm时，在人工动脉外壁处测量的直径也增加。总体而言，在打印和商业支架中，压力和动脉壁运动与脂质斑块之间存在密切的线性关系，尽管AM技术制成的支架的柔韧性和弹性低于商业支架
Atherosclerotic plaque is one of the arterial diseases which builds up in the arterial wall and can be identified by the composition of the plaque. Atherosclerosis causes the narrowing or occlusions of the arterial lumen leading to cardiovascular event. Percutaneous (keyhole) endovascular stenting has become the most common revascularisation method due to its minimum invasive nature and low complication rate. The stents, mostly fabricated by laser machines, have uniform geometries which are not ideal to treat the diseased arteries with lesion-specific properties. In addition, the effect of arterial plaque compositions on the performance of stents is not fully investigated. In this study, the deployment performance of the stents with the varied design, made of the 316L stainless steel and fabricated by additive manufacturing (AM) technology, were investigated. An in vitro experiment was conducted to test the influence of the atherosclerotic plaque compositions at 55% stenosis on the commercial and AM fabricated stents. Two artificial plaques (lipid and calcified) were prepared manually, and their mechanical testing were conducted using an unconfined compression test. Two types of stents, printed and commercial stents, were used to treat the diseased artificial artery, and the data of the pressure and diameter were collected simultaneously when the stent inflation pressure was applied. The results show that the mechanical property of the artificial lipid plaques was very similar to the real lipid plaque that observed from clinical study. From the deployment performance test for these two types of stents, it was observed that as the pressure inside of balloon increases, the diameters measured at the external wall of the artificial artery also increase when the pressure is above 4 atm. Overall, there is a close linear relationship between pressure and arterial wall movement with lipid plaque in both printed and commercial stents though that the stent made of AM technology is less flexible and has lower elastic property than the commercial one