Asymmetric synthesis of anti-ýý-substituted ýý-amino ketones from sulfinimines.
Asymmetric synthesis of anti-ýý-substituted ýý-amino ketones from sulfinimines.
复制标题
从亚磺胺不对称合成反-α-取代α-氨基酮。
DOI：
10.1021/jo2002352
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Xu,Peng
中科院分区：
文献类型：
--
作者：
Davis,FranklinA;Xu,Peng
Previously unknown, enantiopure, β-amino ketones were prepared in modest yield by addition of lithium reagents toN-sulfinylanti-α-substituted β-amino Weinreb amides. Grignard reagents failed to add to these Weinreb amides in contrast to thesyn-α-substituted isomers which did. Theanti-α-substituted β-amino Weinreb amides were prepared by addition of LiN(OMe)Me to the correspondingN-sulfinylanti-α-substituted β-amino esters because α-alkylation ofN-sulfinyl β-amino Weinreb amide enolates resulted in poor diastereoselectivities.
