Arousal modulation of memory and amygdala-parahippocampal connectivity: A PET-psychophysiology study in specific phobia
Arousal modulation of memory and amygdala-parahippocampal connectivity: A PET-psychophysiology study in specific phobia
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DOI：
10.1111/j.1469-8986.2011.01231.x
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发表时间：
2011-11-01
期刊：
影响因子：
3.7
通讯作者：
Fredrikson, Mats
中科院分区：
文献类型：
--
作者：
Ahs, Fredrik;Palmquist, Asa Michelgard;Fredrikson, Mats
恐惧症伴随着杏仁核调节的强烈的身体反应。杏仁核调节的与唤醒相关的心理生理指标是皮肤电活动。在蜘蛛恐惧症或蛇恐惧症受试者的恐惧记忆编码过程中，我们评估了皮肤电活动对杏仁核-海马区局部脑血流量(RCBF)的贡献。与恐惧症相关的幻灯片的再认记忆增强，并与杏仁核和海马旁回的rCBF共同变化。海马区rCBF与再认之间的协变性与皮肤电活动有关，提示海马区旁记忆过程与交感神经活动有关。皮肤电活动进一步介导杏仁核对海马旁活动的影响。因此，恐惧症期间的记忆编码似乎取决于杏仁核对觉醒和海马旁活动的影响。
Phobic fear is accompanied by intense bodily responses modulated by the amygdala. An amygdala moderated psychophysiological measure related to arousal is electrodermal activity. We evaluated the contributions of electrodermal activity to amygdala-parahippocampal regional cerebral blood flow (rCBF) during phobic memory encoding in subjects with spider or snake phobia. Recognition memory was increased for phobia-related slides and covaried with rCBF in the amygdala and the parahippocampal gyrus. The covariation between parahippocampal rCBF and recognition was related to electrodermal activity suggesting that parahippocampal memory processes were associated with sympathetic activity. Electrodermal activity further mediated the amygdala effect on parahippocampal activity. Memory encoding during phobic fear therefore seems contingent on amygdala's influence on arousal and parahippocampal activity.