Self-reported sleep duration and daytime napping are associated with renal hyperfiltration in general population
Self-reported sleep duration and daytime napping are associated with renal hyperfiltration in general population
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自我报告的睡眠持续时间和白天小睡与普通人群的肾脏高滤过相关
DOI：
10.1007/s11325-017-1470-0
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发表时间：
2018-03-01
影响因子：
2.5
通讯作者：
Chen, Gang
中科院分区：
文献类型：
--
作者：
Lin, Miao;Su, Qing;Chen, Gang
肾超滤（RHF）已成为糖尿病和代谢综合征等多种疾病早期肾损害的新标志物。异常的睡眠时间和过度的日间小睡可能会影响慢性肾脏病（CKD）的发展。在这项研究中，睡眠时间，白天小睡和肾脏超滤之间的关系进行了评估。这项研究在中国的三个社区进行。共有16，119名社区志愿者。（5735名男性和10名，研究包括年龄在40-65岁之间的无CKD的384名女性。（< 6小时/天）或睡眠时间长（10小时/天）的患者发生肾超滤的风险显著增加。完全校正OR（95% CI）分别为2.112（1.107，4.031）和2.071（1.504，2.853）（P < 0.05）。此外，每天午睡时间超过1.5小时的患者发生肾超滤的风险高于不午睡的患者（OR 1.400，95%CI 1.018-1.924）。进一步的联合分析表明，与那些每天睡眠8-9小时而没有白天小睡的人相比，睡眠时间长（10小时/天）的参与者患RHF的风险增加了两倍以上，无论午睡状态如何。睡眠持续时间或白天小睡与RHF之间的关联不能用睡眠质量的影响来解释。额外的亚组分析显示睡眠持续时间长（9小时/天）和长时间的白天小睡睡眠质量好的人群中，睡眠时间<6 h/d或> 10 h/d和白天午睡时间过长与肾超滤风险增加有关，这种关系与糖尿病、高血压、肥胖或睡眠质量差无关。
Renal hyperfiltration (RHF) has emerged as a novel marker of early renal damage in various conditions such as diabetes and metabolic syndrome. Aberrant sleep duration and excessive daytime napping may affect the development of chronic kidney disease (CKD). In this study, the association between sleep duration, daytime napping, and renal hyperfiltration was assessed.This study was conducted in three communities in China.A total of 16,119 community volunteers (5735 males and 10,384 females) aged 40-65 years without CKD were included for the study.Participants with short sleep duration (< 6 h/day) or long sleep duration (a 10 h/day) were at a significantly increased risk of renal hyperfiltration. The fully adjusted ORs (95% CI) were 2.112 (1.107, 4.031) and 2.071 (1.504, 2.853), respectively (P < 0.05). In addition, those who took naps longer than 1.5 h per day had a higher risk of renal hyperfiltration compared with those without napping (OR 1.400, 95% CI 1.018-1.924). Further joint analysis indicated that participants with long sleep duration (a 10 h/day) had a more than twofold increased risk of RHF regardless of nap status compared with those who slept 8-9 h per day without daytime napping. The association between sleep duration or daytime napping and RHF could not be explained by the influence of sleep quality. Additional subgroup analysis showed long sleep duration (a 9 h/day) and long daytime napping (a 1.5 h) were associated with an increased risk of RHF among individuals with good sleep quality.Sleep duration less than 6 h/day or more than 10 h/day and long daytime napping tend to be associated with an increased risk of renal hyperfiltration in middle-aged general population, and this relationship was independent of diabetes, hypertension, obesity, or poor sleep quality.