p53-independent functions of the p19ARF tumor suppressor
p53-independent functions of the p19ARF tumor suppressor
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DOI：
10.1101/gad.827300
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发表时间：
2000-09-15
影响因子：
10.5
通讯作者：
Zambetti, GP
中科院分区：
文献类型：
--
作者：
Weber, JD;Jeffers, JR;Zambetti, GP
The p19(ARF) tumor suppressor antagonizes Mdm2 to induce p53-dependent cell cycle arrest. Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop multiple tumors at a frequency greater than those observed in animals lacking both p53 and Mdm2 or p53 alone, demonstrating that p19(ARF) can act independently of the Mdm2-p53 axis in tumor surveillance. Reintroduction of ARF into TKO mouse embryo fibroblasts (MEFs), but not into those lacking both p53 and ARF, arrested the cell division cycle in the G1 phase. Inhibition of the retinoblastoma protein had no effect on the ability of ARF to arrest TKO MEFs. Thus, in the absence of Mdm2, p19(ARF) interacts with other targets to inhibit cell proliferation.
