Adenomatoid tumors of the female and male genital tracts express WT1
Adenomatoid tumors of the female and male genital tracts express WT1
复制标题
DOI：
10.1097/00004347-200404000-00006
复制
发表时间：
2004-04-01
影响因子：
2.4
通讯作者：
Longacre, TA
中科院分区：
文献类型：
--
作者：
Schwartz, EJ;Longacre, TA
腺瘤样肿瘤是一种良性增生，最常见于女性和男性生殖道。这些不寻常肿瘤的间皮表型已通过各种超微结构和免疫组织化学研究确定，尽管其病因尚不确定。Wilms肿瘤抑制基因WT1在正常、增生和恶性间皮细胞中的表达，促使我们分析了发生在子宫、输卵管、卵巢、附睾、阴囊和睾丸的一系列24个腺瘤样肿瘤中WT1的表达模式。23例肿瘤表达WT1蛋白，同样数量的肿瘤表达calretinin， calretinin是间皮分化的另一个标志。一个calretinin染色失败的肿瘤WT1阳性。这些结果为腺瘤样肿瘤的间皮分化提供了进一步的支持，并提示WT1表达的存在可能有助于这些罕见肿瘤的鉴别诊断，特别是当它们出现在不寻常的环境中或其他间皮标志物表达缺失时。
Adenomatoid tumors are benign proliferations most often encountered in the female and male genital tracts. The mesothelial phenotype of these unusual tumors has been established by a variety of ultrastructural and immunohistochemical studies, although their etiology is by no means certain. The expression of the Wilms' tumor suppressor gene, WT1, in normal, hyperplastic, and malignant mesothelial cells prompted us to analyze the expression pattern of WT1 in a series of 24 adenomatoid tumors occurring in the uterus, fallopian tube, ovary, epididymis, scrotum, and testis. Twenty-three of the tumors expressed WT1 protein and the same number expressed calretinin, another marker of mesothelial differentiation. The one tumor that failed to stain with calretinin was positive for WT1. These results provide further support for mesothelial differentiation of adenomatoid tumors and suggest that the presence of WT1 expression may be useful in the differential diagnosis of these uncommon neoplasms, especially when they present in unusual settings or expression of other mesothelial markers is absent.