A case of methotrexate-associated Epstein-Barr virus-positive mucocutaneous ulcer.
A case of methotrexate-associated Epstein-Barr virus-positive mucocutaneous ulcer.
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DOI：
10.1002/ski2.108
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发表时间：
2022-06
影响因子：
--
通讯作者：
Honda, Tetsuya
中科院分区：
文献类型：
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作者：
Sakamoto, Keiko;Baba, Takeshi;Takatori, Hiroaki;Nagao, Keisuke;Misawa, Junko;Honda, Tetsuya
eb病毒阳性粘膜皮肤溃疡（EBVMCU）是一种B细胞增生性疾病，在2017年世界卫生组织淋巴样肿瘤分类中被指定为临时实体。虽然EBVMCU可能含有不同数量的具有霍奇金细胞和里德-斯滕伯格细胞样形态的细胞，但临床过程是良性的，必须与淋巴瘤区分开来。EBVMCU患者通常免疫功能低下，甲氨蝶呤（MTX）是主要原因。大多数先前报道的EBVMCU病例描述粘膜溃疡，很少有关于皮肤病变及其病程的文献记录。在这里，我们报告了一例MTX相关的下肢EBVMCU，在MTX停药后发生自发消退，在此期间证实了局部Epstein - Barr病毒激活的阴性转化。
Epstein‐Barr virus‐positive mucocutaneous ulcer (EBVMCU) is a B‐cell proliferative disorder that has been designated as a provisional entity in the 2017 World Health Organization classification for lymphoid neoplasms. While EBVMCU may contain varying numbers of cells with Hodgkin and Reed‐Sternberg cells‐like morphology, the clinical course is benign and must be distinguished from lymphomas. Patients who develop EBVMCU are commonly immunocompromised, with methotrexate (MTX) as the leading cause. Most previously reported cases of EBVMCU describe mucosal ulcers with very little documentation on skin lesions and its course. Here, we report a case of MTX‐associated EBVMCU of the lower leg that underwent spontaneous regression after MTX withdrawal, during which negative conversion of local Epstein‐Barr virus activation was confirmed.