Dienediamine: A safe surrogate for the herbicide paraquat
Dienediamine: A safe surrogate for the herbicide paraquat
复制标题
DOI：
10.1016/j.molp.2023.10.018
复制
发表时间：
2023-12-04
期刊：
影响因子：
27.5
通讯作者：
Peng，Ai
中科院分区：
文献类型：
--
作者：
Peng，Henian;Zhao，Dake;Peng，Ai
百草枯（PQ）因其强大的抗杂草活性而在世界范围内被广泛用作除草剂。然而，它对人类是剧毒的。PQ中毒的高致死率是由于其固有的毒性和缺乏任何有效的治疗。因此，开发一种与PQ功效相当的无毒除草剂将有助于全球粮食安全，并有助于防止PQ相关的死亡。在此，我们报道了一种名为二烯二胺的新型除草剂，它是从如何干预PQ的氧化还原循环中发现的，其固有的毒性性质。二烯二胺作为PQ的“还原”形式，不具有电子转移剂的功能，在相当于PQ绝对致死剂量的摩尔浓度下，通过全面的体内和体外实验证明是无毒的。值得注意的是，在自然光照和环境空气条件下，二烯二胺可以转化为PQ，表现出与PQ相当的除草活性。二烯二胺转化为PQ是其通过叶绿体毒性产生强除草活性的关键机制。我们的研究表明，二烯二胺是一种安全、优越的PQ替代品，在全球可持续农业中具有重要的应用潜力。
Paraquat (PQ) has been used as an herbicide worldwide because of its potent activity against weeds. However, it is highly toxic to humans. The very high fatality of PQ poisoning is due to its inherent toxicity and the lack of any effective treatment. Consequently, developing a non-toxic herbicide with comparable efficacy to PQ will contribute to global food security and help prevent PQ-related fatalities. Herein, we report new herbicide called dienediamine, which was discovered from how to intervene the redox cycle of PQ, an inherent toxicity nature. The dienediamine as the" reduced" form of PQ, with no function as an electron transfer agent, proven to be non-toxic through comprehensive in vivo and in vitro experiments at molar concentrations equivalent to PQ's absolute lethal dose. Remarkably, dienediamine can undergo conversion to PQ under natural sunlight and ambient air conditions, exhibiting herbicidal activities that are comparable to those of PQ. The conversion of dienediamine to PQ is the key mechanism underlying its potent herbicidal activity through the chloroplast toxicity. Our study presents dienediamine as a safe and superior alternative to PQ, possessing significant potential for application in sustainable agriculture globally.