Bacterial resistance to antibiotics as a function of outer membrane permeability.
Bacterial resistance to antibiotics as a function of outer membrane permeability.
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DOI：
10.1093/jac/22.supplement_a.17
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发表时间：
1988-07
期刊：
影响因子：
--
通讯作者：
Hiroshi Nikaido
中科院分区：
文献类型：
--
作者：
Hiroshi Nikaido
革兰氏阴性菌的外膜作为渗透屏障。穿过该屏障的运输通常通过孔蛋白产生的通道发生。这些孔蛋白的变化可以解释抗生素耐药性。渗透屏障和周质空间中的β-内酰胺酶的组合导致甚至第三代头孢菌素在靶点处的浓度可以显著降低的情况。
The outer membrane of Gram-negative bacteria serves as barrier to permeation. Transport across this barrier often occurs through channels created by porins. Changes in these porins can account for antibiotic resistance. The combination of a permeability barrier and beta-lactamases in the periplasmic space leads to a situation in which concentrations, at the target, of even third-generation cephalosporins, can be significantly decreased.