Altered plasma concentrations of leptin, transforming growth factor-β1 and plasminogen activator inhibitor type 2 at 18 weeks of gestation in women destined to develop pre-eclampsia.: Circulating markers of disturbed placentation?
Altered plasma concentrations of leptin, transforming growth factor-β1 and plasminogen activator inhibitor type 2 at 18 weeks of gestation in women destined to develop pre-eclampsia.: Circulating markers of disturbed placentation?
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DOI：
10.1053/plac.2002.0828
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发表时间：
2002-05-01
期刊：
影响因子：
3.8
通讯作者：
Henriksen, T
中科院分区：
文献类型：
--
作者：
Clausen, T;Djurovic, S;Henriksen, T
背景资料。在许多子痫前期妇女中，胎盘形成过程似乎受到干扰。我们的目的是调查先兆子痫妇女的胎盘形成障碍是否可以在妊娠早期被识别为参与子宫胎盘单位形成的因素的血浆水平的改变。在一项对2190名孕妇的前瞻性研究中，我们比较了71名随后患有子痫前期的孕妇和71名对照组在妊娠18周时血浆瘦素、转化生长因子-β(1)和纤溶酶原激活物抑制物-2(PAI-2)的浓度。与对照组相比，子痫前期患者瘦素和转化生长因子-β(1)浓度降低，PAI-2浓度升高(瘦素：中位数(25-75百分位数)：19.0(14.5-29.0)ng/ml对25.0(16.0-35.0)ng/ml(p=0.03)；转化生长因子β(1)：3.2vs5.3(3.87.1)ng/ml(P=0.002)；PAI2：78.8vs67.6vs67.6(61.6vs79.6)ng/ml(P=0.002)。与后四分位数相比，上四分位数与下四分位数相比，子痫前期的OR(95%CI)分别为：瘦素：0.2(0.03~0.7)，转化生长因子-β(1)，0.2(0.08~0.7)，PAI-2：3.1(1.2~8.2)。子痫前期患者胎盘形成过程中参与因素的血浆浓度水平的变化，表明子宫胎盘单位的形成障碍在妊娠20周前反映在母亲的循环中。(C)2002爱思唯尔科学有限公司。保留所有权利。
Background. In many pre-eclamptic women the placentation process seems to be disturbed. Our objective was to investigate if disturbed placentation in pre-eclamptic women may be recognized in early second trimester as altered plasma levels of factors involved in the formation of the uteroplacental unit.Methods. In a prospective study of 2190 pregnant women we compared plasma leptin, transforming growth factor-beta(1) (TGF-beta(1)) and plasminogen activator inhibitor type 2 (PAI-2) concentrations at 18 weeks' gestation in 71 women with subsequent pre-eclampsia and 71 controls matched for age, parity and first trimester bode mass index.Results. Leptin and TGF-beta(1), concentrations were lower and PAI-2 concentration higher in women destined to develop pre-eclampsia relative to controls (leptin: median (25-75 percentiles): 19.0 (14.5-29.0) vs 25.0 (16.0-35.0)ng/ml (p =0.03), TGF-beta(1): 3.2 (2.0-6.1) vs 5.3 (3.8-7.1) ng/ml (P=0.01) and PAI-2: 78.8 (65.1-118.1) vs 67.6 (61.6-79.6) ng/ml (P=0.002)). OR (95 per cent CI) for pre-eclampsia for women in the upper quartile compared to women in the lower quartile were: leptin: 0.2 (0.03-0.7), TGF-beta(1),: 0.2 (0.08-0.7) and PAI-2: 3.1 (1.2-8.2).Conclusion. Altered plasma concentrations levels of factors involved in the process of placentation in women destined to develop pre-eclampsia, indicate that disturbed formation of the uteroplacental unit is reflected in the maternal circulation before 20 weeks' gestation. (C) 2002 Elsevier Science Ltd. All rights reserved.