Long non-coding RNAs in development and disease: conservation to mechanisms.
Long non-coding RNAs in development and disease: conservation to mechanisms.
复制标题
DOI：
10.1002/path.5405
复制
发表时间：
2020-04
期刊：
影响因子：
--
通讯作者：
Aspden JL
中科院分区：
文献类型：
--
作者：
Tsagakis I;Douka K;Birds I;Aspden JL
我们的基因组包含了使我们成为人类的蓝图，以及我们为什么会患上疾病的许多迹象。直到最近10年，大多数研究都集中在蛋白质编码基因上，更具体地说，是编码蛋白质的DNA序列。然而，这只占我们基因组的不到5%。另外95%被称为我们基因组的“暗物质”，我们对它的理解非常有限。这种“暗物质”的一部分包括产生不编码蛋白质的rna的区域。这些非编码rna的一个子集是长链非编码rna (lncRNAs)，特别是它们开始被解剖，并揭示了它们对人类健康的重要性。为了提高我们对疾病的理解和治疗，了解lncrna的分子和细胞功能，以及它们的错误调控如何导致疾病是至关重要的。目前尚不清楚lncrna中实际起作用的比例；进化过程中的保护被用来理解lncRNA的生物学重要性。在这里，我们提出了lncrna领域的关键主题，强调了它们在细胞核和细胞质中的作用的重要性，以及它们的作用模式。我们用我们最了解的例子来讨论它们在发育和疾病中的潜在功能。最后，我们强调了为什么lncrna可以作为生物标志物，并讨论了它们在治疗中的新潜力。©2020作者。由John Wiley & Sons Ltd代表大不列颠和爱尔兰病理学会出版的病理学杂志。
Our genomes contain the blueprint of what makes us human and many indications as to why we develop disease. Until the last 10 years, most studies had focussed on protein‐coding genes, more specifically DNA sequences coding for proteins. However, this represents less than 5% of our genomes. The other 95% is referred to as the ‘dark matter’ of our genomes, our understanding of which is extremely limited. Part of this ‘dark matter’ includes regions that give rise to RNAs that do not code for proteins. A subset of these non‐coding RNAs are long non‐coding RNAs (lncRNAs), which in particular are beginning to be dissected and their importance to human health revealed. To improve our understanding and treatment of disease it is vital that we understand the molecular and cellular function of lncRNAs, and how their misregulation can contribute to disease. It is not yet clear what proportion of lncRNAs is actually functional; conservation during evolution is being used to understand the biological importance of lncRNA. Here, we present key themes within the field of lncRNAs, emphasising the importance of their roles in both the nucleus and the cytoplasm of cells, as well as patterns in their modes of action. We discuss their potential functions in development and disease using examples where we have the greatest understanding. Finally, we emphasise why lncRNAs can serve as biomarkers and discuss their emerging potential for therapy. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
登录
查看更多内容
DOI：
10.1261/rna.053561.115
发表时间：
2016-06
期刊：
RNA (New York, N.Y.)
影响因子：
--
作者：
Carlevaro-Fita J;Rahim A;Guigó R;Vardy LA;Johnson R
通讯作者：
Johnson R
影响因子：
64.8
作者：
Carrieri, Claudia;Cimatti, Laura;Gustincich, Stefano
通讯作者：
Gustincich, Stefano
DOI：
10.1126/science.aal2512
发表时间：
2017-06-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Almeida M;Pintacuda G;Masui O;Koseki Y;Gdula M;Cerase A;Brown D;Mould A;Innocent C;Nakayama M;Schermelleh L;Nesterova TB;Koseki H;Brockdorff N
通讯作者：
Brockdorff N
影响因子：
14.9
作者：
Frankish A;Diekhans M;Ferreira AM;Johnson R;Jungreis I;Loveland J;Mudge JM;Sisu C;Wright J;Armstrong J;Barnes I;Berry A;Bignell A;Carbonell Sala S;Chrast J;Cunningham F;Di Domenico T;Donaldson S;Fiddes IT;García Girón C;Gonzalez JM;Grego T;Hardy M;Hourlier T;Hunt T;Izuogu OG;Lagarde J;Martin FJ;Martínez L;Mohanan S;Muir P;Navarro FCP;Parker A;Pei B;Pozo F;Ruffier M;Schmitt BM;Stapleton E;Suner MM;Sycheva I;Uszczynska-Ratajczak B;Xu J;Yates A;Zerbino D;Zhang Y;Aken B;Choudhary JS;Gerstein M;Guigó R;Hubbard TJP;Kellis M;Paten B;Reymond A;Tress ML;Flicek P
通讯作者：
Flicek P
DOI：
10.1158/1541-7786.mcr-14-0251
发表时间：
2015-02
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Eades G;Wolfson B;Zhang Y;Li Q;Yao Y;Zhou Q
通讯作者：
Zhou Q