Microwave-Assisted Tandem Processes for the Synthesis of N-Heterocycles
Microwave-Assisted Tandem Processes for the Synthesis of N-Heterocycles
复制标题
DOI：
10.1071/ch08474
复制
发表时间：
2009-01-01
影响因子：
1.1
通讯作者：
Huang, Xudong
中科院分区：
文献类型：
--
作者：
Abid, Mohammed;Torok, Bela;Huang, Xudong
近年来，微波辅助有机合成（MAOS）已成为合成杂环化合物的主流工具。在这一领域的广泛新兴应用主要是由于MAOS对开发生态友好型工艺的重大贡献。在微波条件下，N-杂环化合物的合成已发展出多种转化方法，包括快速和选择性的方法。串联反应涉及绿色的反应介质，无溶剂的条件下，和固相合成在这一领域的特殊利益。在大多数转化中，微波条件显著地提高了反应速率，并且提供了改进的产率。该帐户强调了最新的进展MAOS为基础的串联过程中的N-杂环的合成。
Over the years, microwave-assisted organic synthesis (MAOS) became a commonly applied mainstream tool for the synthesis of heterocyclic compounds. The broad range of emerging applications in this field is mainly due to the significant contribution of MAOS to the development of ecofriendly processes. Various transformations have been developed for the synthesis of N-heterocycles under microwave conditions, including fast and selective processes. Tandem reactions involving greener reaction media, solvent-free conditions, and solid-phase synthesis are of exceptional interest in this area. In most transformations, microwave conditions dramatically enhanced reaction rates, as well as provided improved yields. This account highlights the most recent advancements in MAOS-based tandem processes for the synthesis of N-heterocycles.