From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia.
From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia.
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DOI：
10.1155/2016/2536705
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发表时间：
2016
影响因子：
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通讯作者：
Dobreanu M
中科院分区：
文献类型：
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作者：
Bănescu C;Iancu M;Trifa AP;Cândea M;Benedek Lazar E;Moldovan VG;Duicu C;Tripon F;Crauciuc A;Dobreanu M
氧化应激可能导致癌症的发生，包括血液系统癌症。各种遗传多态性被证明会增加活性氧的数量，这种现象能够诱导突变，从而促进癌症。本研究的目的是评估CAT C262T、GPX1 Pro198Leu、MnSOD Ala16Val、GSTM1、GSTT1和GSTP1 Ile105Val基因多态性与急性髓系白血病风险之间的关系，采用病例对照研究，包括102例患者和303例对照。未观察到AML与CAT、MnSOD、GSTM1和GSTT1多态性的变异基因型之间的关联。我们的数据显示AML患者和对照组之间GPX1 Pro198Leu和GSTP1 Ile105Val变异基因型的频率存在统计学显著差异（p < 0.001）。我们的研究结果显示，CAT C262T、GPX1 Pro198Leu、GSTM1、GSTT1和GSTP1多态性的分布与年龄、性别、FAB亚型、细胞遗传学风险组、FLT3和DNMT3基因突变以及总生存率无关。提示GPX1 Pro198Leu和GSTP1 Ile105Val基因多态性的变异等位基因和基因型的存在可能调节AML的发病风险。
Oxidative stress might contribute to the occurrence of cancers, including the hematological ones. Various genetic polymorphisms were shown to increase the quantity of reactive oxygen species, a phenomenon that is able to induce mutations and thus promote cancers. The purpose of the study was to evaluate the association between CAT C262T, GPX1 Pro198Leu, MnSOD Ala16Val, GSTM1, GSTT1, and GSTP1 Ile105Val gene polymorphisms and acute myeloid leukemia risk, in a case-control study comprising 102 patients and 303 controls. No association was observed between AML and variant genotypes of CAT, MnSOD, GSTM1, and GSTT1 polymorphisms. Our data revealed a statistically significant difference regarding the frequencies of GPX1 Pro198Leu and GSTP1 Ile105Val variant genotypes between AML patients and controls (p < 0.001). Our results showed no association in the distribution of any of the CAT C262T, GPX1 Pro198Leu, GSTM1, GSTT1, and GSTP1 polymorphisms regarding age, gender, FAB subtype, cytogenetic risk groups, FLT3 and DNMT3 gene mutations, and overall survival. Our data suggests that the presence of variant allele and genotype of GPX1 Pro198Leu and GSTP1 Ile105Val gene polymorphisms may modulate the risk of developing AML.