Activated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections
Activated antigen-specific CD8+ T cells persist in the lungs following recovery from respiratory virus infections
复制标题
DOI：
10.4049/jimmunol.166.3.1813
复制
发表时间：
2001-02-01
影响因子：
4.4
通讯作者：
Woodland, DL
中科院分区：
文献类型：
--
作者：
Hogan, RJ;Usherwood, EJ;Woodland, DL
对呼吸道病毒感染的细胞免疫与次级淋巴器官中记忆性CD8(+) T细胞数量之间的相关性较差，这表明针对此类感染可能存在其他的T细胞记忆库。在此，我们在肺部发现了大量的抗原特异性T细胞，这些细胞在流感或仙台病毒感染恢复后可存在数月之久。这些细胞在气道和肺实质中大量存在，并且在CD8(+) T细胞中的相对频率、活化状态以及持续存在的动力学方面，可与脾脏和外周淋巴结中的记忆细胞群区分开来。此外，这些细胞在增殖能力、表达细胞溶解活性以及分泌细胞因子方面具有功能，尽管它们不表达组成性细胞溶解活性。过继转移实验表明，肺部活化T细胞的长期存在并不需要携带诱导抗原的病原体在肺部感染。肺部抗原特异性CD8(+) T细胞的持续存在动力学表明，它们在针对呼吸道病毒感染的保护性细胞免疫中起着关键作用。
The poor correlation between cellular immunity to respiratory virus infections and the numbers of memory CD8(+) T cells in the secondary lymphoid organs suggests that there may be additional reservoirs of T cell memory to this class of infection. Here we identify a substantial population of Ag-specific T cells in the lung that persist for several months after recovery from an influenza or Sendai virus infection. These cells are present in high numbers in both the airways and lung parenchyma and fan be distinguished from memory cell populations in the spleen and peripheral lymph nodes in terms of the relative frequencies among CD8(+) T cells, activation status, and kinetics of persistence. In addition, these cells are functional in terms of their ability to proliferate, express cytolytic activity, and secrete cytokines, although they do not express constitutive cytolytic activity. Adoptive transfer experiments demonstrated that the long-term establishment of activated T cells in the lung did not require infection in the lung by a pathogen carrying the inducing Ag, The kinetics of persistence of Ag-specific CD8(+) T cells in the lung suggests that they play a key role in protective cellular immunity to respiratory virus infections.