Genome of the small hive beetle (Aethina tumida, Coleoptera: Nitidulidae), a worldwide parasite of social bee colonies, provides insights into detoxification and herbivory
Genome of the small hive beetle (Aethina tumida, Coleoptera: Nitidulidae), a worldwide parasite of social bee colonies, provides insights into detoxification and herbivory
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DOI：
10.1093/gigascience/giy138
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发表时间：
2018-12-07
期刊：
影响因子：
9.2
通讯作者：
Huang, Qiang
中科院分区：
文献类型：
--
作者：
Evans, Jay D.;McKenna, Duane;Huang, Qiang
研究背景：膨胀小蜂（Aethina tumida; ATUMI）是一种入侵蜂群的寄生虫。ATUMI以水果和蜂巢产品为食，促进了其传播，并增加了其对蜜蜂和其他授粉者的影响。我们已经对ATUMI基因组进行了测序和注释，为该物种和Nitidulidae提供了第一个基因组资源，Nitidulidae是一个与被称为Phytophaga的非常丰富的甲虫分支密切相关的甲虫家族。因此，ATUMI作为已知最成功的动物群体之一的邻居，提供了一个对比鲜明的观点。结果：我们提出了一个强大的基因组组装和基因集拥有97.5%的核心蛋白已知的全变态昆虫。ATUMI基因组编码的植物消化酶比食木甲虫的基因组少，但仍然显示出广泛的代谢可塑性的迹象。与其他甲虫相比，味觉受体的数量很少，特别是已知对苦味物质敏感的受体（在其他甲虫中）。与此相反，涉及杀虫剂解毒和适应不同饮食资源的几个基因家族的拷贝数增加。参与解毒的同系物的存在和多样性与ATUMI的蜜蜂宿主有很大不同。结论：我们的研究结果为ATUMI局部适应和入侵的基因组基础提供了新的见解，并为针对这种害虫而不伤害蜜蜂宿主的控制策略提供了蓝图。一组最小的味觉感受器是一致的观察，一旦宿主殖民地被入侵，食物资源是可预测的。独特的解毒途径和途径成员可以帮助确定哪些治疗方法可以控制这个物种，即使在蜜蜂的存在下，这是出了名的对杀虫剂敏感。
Background: The small hive beetle (Aethina tumida; ATUMI) is an invasive parasite of bee colonies. ATUMI feeds on both fruits and bee nest products, facilitating its spread and increasing its impact on honey bees and other pollinators. We have sequenced and annotated the ATUMI genome, providing the first genomic resources for this species and for the Nitidulidae, a beetle family that is closely related to the extraordinarily species-rich clade of beetles known as the Phytophaga. ATUMI thus provides a contrasting view as a neighbor for one of the most successful known animal groups. Results: We present a robust genome assembly and a gene set possessing 97.5% of the core proteins known from the holometabolous insects. The ATUMI genome encodes fewer enzymes for plant digestion than the genomes of wood-feeding beetles but nonetheless shows signs of broad metabolic plasticity. Gustatory receptors are few in number compared to other beetles, especially receptors with known sensitivity (in other beetles) to bitter substances. In contrast, several gene families implicated in detoxification of insecticides and adaptation to diverse dietary resources show increased copy numbers. The presence and diversity of homologs involved in detoxification differ substantially from the bee hosts of ATUMI. Conclusions: Our results provide new insights into the genomic basis for local adaption and invasiveness in ATUMI and a blueprint for control strategies that target this pest without harming their honey bee hosts. A minimal set of gustatory receptors is consistent with the observation that, once a host colony is invaded, food resources are predictable. Unique detoxification pathways and pathway members can help identify which treatments might control this species even in the presence of honey bees, which are notoriously sensitive to pesticides.