Gender and age patterns in HSV-2 and HIV infection among non-injecting drug users in New York City.
Gender and age patterns in HSV-2 and HIV infection among non-injecting drug users in New York City.
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DOI：
10.1097/olq.0b013e3181e1a64a
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发表时间：
2010-10
影响因子：
3.1
通讯作者：
Friedman SR
中科院分区：
文献类型：
--
作者：
Des Jarlais DC;Arasteh K;McKnight C;Perlman D;Hagan H;Semaan S;Friedman SR
目的：探讨纽约市从未注射过海洛因和可卡因的吸毒者（NIDUs）中单纯疱疹病毒2型（HSV-2）感染与HIV感染的流行情况及两者之间的关系。受试者是从进入贝斯以色列戒毒计划的患者中招募的。获得知情同意后，进行人口统计、用药史和性危险行为等结构化问卷调查，并采集血样进行HIV和HSV-2抗体检测。在2005年7月至2009年6月期间，共招募了1418名从未（终生）注射药物（NIDUs）的受试者。受试者主要为男性（76%），黑人（67%）或西班牙裔（25%），报告近期使用快克可卡因（74%），平均年龄42岁。11%的男性报告了男性与男性之间的性行为。两种病毒的流行率都很高：HSV-2在总样本中占61%，在非男男性行为者中占50%，在女性中占85%，在男男性行为者中占72%；艾滋病毒在总样本中占16%，在非男同性恋者中占12%，在女性中占20%，在男同性恋者中占46%。HSV-2与HIV相关（OR = 3.2, 95% CI: 2.3-4.5; PR = 2.7, 95% CI: 2.0-3.7）。性别和年龄组的分析表明，这两种病毒的单一感染和合并感染的模式不同。这些非注射吸毒者中2型单纯疱疹病毒和艾滋病毒的发病率与撒哈拉以南非洲的发病率相当。迫切需要针对性别和年龄组的额外预防规划。此外，还需要新的平台为非本地居民提供服务。
To examine prevalence of and associations between herpes simplex virus type 2 (HSV-2) infection and HIV infection among never-injecting heroin and cocaine drug users (NIDUs) in New York City. Subjects were recruited from patients entering the Beth Israel drug detoxification program. Informed consent was obtained, a structured questionnaire including demographics, drug use history, and sexual risk behavior was administered, and a blood sample was collected for HIV and HSV-2 antibody testing. A total of 1418 subjects who had never (lifetime) injected drugs (NIDUs) were recruited between July 2005 through June 2009. Subjects were primarily male (76%), and black (67%) or Hispanic (25%), reported recent crack cocaine use (74%), and had a mean age of 42 years. Eleven percent of males reported male-with-male sexual (MSM) behavior. The prevalence of both viruses was high: for HSV-2, 61% among the total sample, 50% among non-MSM males, 85% among females, and 72% among MSM; for HIV, 16% among the total sample, 12% among non-MSM males, 20% among females, and 46% among MSM. HSV-2 was associated with HIV (OR = 3.2, 95% CI: 2.3–4.5; PR = 2.7, 95% CI: 2.0–3.7). Analyses by gender and age groups indicated different patterns in mono- and coinfection for the 2 viruses. HSV-2 and HIV rates among these NIDUs are comparable with rates in sub-Saharan Africa. Additional prevention programs, tailored to gender and age groups, are urgently needed. New platforms for providing services to NIDUs are also needed.