Seven valent pneumococcal conjugate vaccine immunization in two Boston communities -: Changes in serotypes and antimicrobial susceptibility among Streptococcus pneumoniae isolates
Seven valent pneumococcal conjugate vaccine immunization in two Boston communities -: Changes in serotypes and antimicrobial susceptibility among Streptococcus pneumoniae isolates
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DOI：
10.1097/01.inf.0000143645.58215.f0
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发表时间：
2004-11-01
影响因子：
3.6
通讯作者：
Marchant, CD
中科院分区：
文献类型：
--
作者：
Pelton, SI;Loughlin, AM;Marchant, CD
背景资料：七价肺炎球菌结合疫苗（PCV 7）于2000年获得许可并引入，用于2岁以下儿童的普遍接种和2-5岁儿童的选择性免疫。具体目的：确定引入PCV 7后肺炎链球菌微生物中定植和抗菌药物敏感性的变化。对2-24个月的婴幼儿进行鼻咽部带菌监测。肺炎。鼻咽部S.在所有健康儿童访视和患有急性中耳炎的儿童的疾病访视中进行肺炎。S. pneumoniae的微生物进行血清分型，和抗菌药物对青霉素，阿莫西林，甲氧苄啶，磺胺甲恶唑和阿奇霉素的敏感性进行了performed.Results：在3年期间（2000年10月至2003年9月），鼻咽定植与疫苗血清型从22%下降到2%，和nonvaccine血清型从7%上升到16%。S.结论：PCV 7免疫接种可使幼儿鼻咽部携带的疫苗血清型明显下降，而非疫苗血清型的流行率则同时上升。迄今为止，尚未观察到抗菌药物敏感性的重要变化。
Background: Seven valent pneumococcal conjugate vaccine (PCV7) was licensed and introduced in 2000 for universal administration of children younger than 2 years of age and for selective immunization of children 2-5 years of age.Specific Aims: To identify changes in colonization and antimicrobial susceptibility among Streptococcus pneumoniae organisms after introduction of PCV7.Methods: Infants and children ages 2-24 months were enrolled in surveillance study of nasopharyngeal carriage of S. pneumoniae. Nasopharyngeal cultures for S. pneumoniae were performed at all well child visits and illness visits of children with acute otitis media. S. pneumoniae organisms were serotyped, and antimicrobial susceptibilities to penicillin, amoxicillin, trimethoprim-sulfamethoxazole and azithromycin were performed.Results: During the 3-year period (October 2000 through September 2003), nasopharyngeal colonization with vaccine serotypes declined from 22% to 2%, and nonvaccine serotypes increased from 7% to 16%. Rates of antibiotic resistance of S. pneumoniae isolates to penicillin, amoxicillin, azithromycin and trimethoprim-sulfamethoxazole were 29.3, 2.2: 26.5 and 28.1%, respectively.Conclusions: PCV7 immunization produces a marked decline in vaccine serotypes carried in the nasopharynx of young children, with a coincident rise in the prevalence of nonvaccine serotypes. Important shifts in antimicrobial susceptibility have not been observed to date.