Depression in patients with refractory temporal lobe epilepsy
Depression in patients with refractory temporal lobe epilepsy
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DOI：
10.1590/s0004-282x2011000600010
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发表时间：
2011-10-01
影响因子：
1.4
通讯作者：
Cendes, Fernando
中科院分区：
文献类型：
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作者：
Gonçalves, Eleonora Borges;Cendes, Fernando
目的：探讨难治性颞叶癫痫(TLE)患者抑郁障碍的共病情况。方法：根据国际疾病分类(ICD-10)和Beck抑郁量表，我们对25例难治性TLE患者(16名女性和9名男性)进行了半结构化精神病学访谈。结果：25例患者中有17例(68%)有抑郁障碍：6例有恶劣心境，3例有严重抑郁发作，8例有反复抑郁障碍。两人(8%)被诊断为焦虑症和抑郁症混合症。17名患者中只有5名(29.4%)以前被诊断为抑郁障碍并接受过抗抑郁治疗。抑郁障碍患者癫痫持续时间明显延长(p=0.016)，但与发作频率无关。结论：本研究证实在抗癫痫药物治疗无效的TLE患者中，抑郁障碍是常见且未被诊断的。癫痫持续时间较长的患者患抑郁症的风险更高。
Objective: To evaluate the comorbidity of depressive disorders in patients with refractory temporal lobe epilepsy (TLE). Method: We evaluated 25 consecutive patients with refractory TLE (16 women and 9 men), using semi-structured psychiatric interviews, according to the International Classification of Diseases (ICD-10), and the Beck Depression Inventory. Results: Seventeen of 25 patients (68%) had depressive disorder: 6 with dysthymia, three with major depressive episodes and 8 with recurrent depressive disorders. Two (8%) were diagnosed with mixed anxiety and depression. Only 5 of 17 patients (29.4%) were previously diagnosed with depressive disorder and received prior antidepressant treatment. Duration of epilepsy was significantly higher in patients with depressive disorder (p=0.016), but there was no relationship between depression and seizure frequency. Conclusion: This study confirmed that depressive disorders are common and underdiagnosed in patients with TLE refractory to AEDs. Patients with longer duration of epilepsy are at higher risk of having depression.