Enantioselective synthesis of chiral sulfones by Ir-catalyzed asymmetric hydrogenation: a facile approach to the preparation of chiral allylic and homoallylic compounds.
Enantioselective synthesis of chiral sulfones by Ir-catalyzed asymmetric hydrogenation: a facile approach to the preparation of chiral allylic and homoallylic compounds.
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DOI：
10.1021/ja306731u
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发表时间：
2012-08
影响因子：
15
通讯作者：
Taigang Zhou;B. Peters;M. F. Maldonado;T. Govender;P. Andersson
中科院分区：
文献类型：
--
作者：
Taigang Zhou;B. Peters;M. F. Maldonado;T. Govender;P. Andersson
发展了一种高效的不饱和砜的不对称选择性铱催化加氢反应。手性环状和非环状砜的产生在良好的对映选择性（高达98%ee）。与Ramberg-Bäcklund重排反应相结合，该反应提供了一种新的路线，手性烯丙基和高烯丙基化合物具有优异的对映选择性（高达97%ee）和高产率（高达94%）。
A highly efficient and enantioselective Ir-catalyzed hydrogenation of unsaturated sulfones was developed. Chiral cyclic and acyclic sulfones were produced in excellent enantioselectivities (up to 98% ee). Coupled with the Ramberg-Bäcklund rearrangement, this reaction offers a novel route to chiral allylic and homoallylic compounds in excellent enantioselectivities (up to 97% ee) and high yields (up to 94%).