REGIONAL CEREBRAL BLOOD-FLOW DURING VOLUNTARY ARM AND HAND MOVEMENTS IN HUMAN-SUBJECTS
REGIONAL CEREBRAL BLOOD-FLOW DURING VOLUNTARY ARM AND HAND MOVEMENTS IN HUMAN-SUBJECTS
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DOI：
10.1152/jn.1991.65.6.1392
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发表时间：
1991-06-01
影响因子：
2.5
通讯作者：
FRACKOWIAK, RSJ
中科院分区：
文献类型：
--
作者：
COLEBATCH, JG;DEIBER, MP;FRACKOWIAK, RSJ
1.采用正电子发射断层扫描技术对6名正常志愿者在安静状态和进行4种不同的右臂重复运动时的局部脑血流量（rCBF）进行测定.这四个动作以随机顺序进行，包括食指外展、握拳、顺序拇指对指和肩部屈曲。所有的运动都是以相同的速度完成的，使用听觉提示，并在每个关节的生理范围内进行类似的位移。rCBF的增加被解释为局部神经激活的证据，所有四种运动都与对侧感觉运动区和运动前区以及补充运动区（SMA）的CBF显著增加相关。肩部运动时对侧感觉运动皮层的平均血流量增加（31%）显著高于其他三种运动。手指相对（21%）和握拳（24%）的增加没有显着差异，两者都显着大于食指运动（13%）。这些数据表明，无论是“分馏”或远端运动本身引起选择性激活的感觉运动皮层。与其他运动相比，肩部运动时对侧运动前皮质和SMA（"非主要运动区"）的血流量显著增加。因为这种差异可能与感觉运动皮层中同时发生的显著更大的激活有关，所以这一发现并不能明确证明非初级运动区在近端运动中的"选择性"作用。与重复收缩相同手指相比，当进行简单的手指运动序列时，两个非主要运动区域都没有显示出选择性激活。肩部运动单独与同侧感觉运动皮层（10%）、小脑上级蚓部（19%）以及对侧大脑半球Brodmann 5区和40区的rCBF显著增加相关。四种运动的感觉运动皮层和SMA中兴奋中心的平均位置不同，并被解释为肢体内躯体化的证据。肩部病灶位于感觉运动皮层最高，SMA最低。
1. Regional cerebral blood flow (rCBF) was measured using positron emission tomography in six normal volunteers while at rest and while performing four different repetitive movements of the right arm.2. The four movements were performed in random order and consisted of abduction of the index finger, making a fist, sequential thumb to digit opposition, and shoulder flexion. All the movements were done at the same rate, using an auditory cue and involved displacements through similar amounts of the physiological range at each joint.3. Increases in rCBF were interpreted as evidence of local neural activation and all four movements were associated with significant increases in CBF in the contralateral sensorimotor and premotor areas and in the supplementary motor area (SMA).4. The average increase in blood flow in the contralateral sensorimotor cortex was significantly greater for the shoulder movement (31%) than for the three other movements. The increases with finger opposition (21%) and fist-making (24%) were not significantly different, and both were significantly greater than with index finger movement (13%). These data indicate that neither "fractionation" nor distal movement per se cause selective activation of sensorimotor cortex.5. Significantly greater increases in blood flow in both the contralateral premotor cortex and the SMA ("nonprimary motor areas") occurred with shoulder movement than with the other movements. Because this difference may be related to the significantly greater activation occurring concurrently in the sensorimotor cortex, this finding does not prove unequivocally a "selective" role of the nonprimary motor areas in proximal movement.6. Neither of the two nonprimary motor areas showed selective activation when a simple sequence of finger movements was performed compared with repetitive contractions of the same fingers.7. Shoulder movement alone was associated with significant increases in rCBF in the ipsilateral sensorimotor cortex (10%), the superior vermis of the cerebellum (19%), and Brodmann areas 5 and 40 in the contralateral hemisphere.8. The average location of the center of excitation in the sensorimotor cortex and SMA differed for the four movements and was interpreted as evidence of within-limb somatotopy. The shoulder focus lay highest in the sensorimotor cortex and lowest in the SMA.