Effect of concomitant HIV infection on presentation and outcome of rotavirus gastroenteritis in Malawian children
Effect of concomitant HIV infection on presentation and outcome of rotavirus gastroenteritis in Malawian children
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DOI：
10.1016/s0140-6736(01)05706-3
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发表时间：
2001-08-18
期刊：
影响因子：
168.9
通讯作者：
Hart, CA
中科院分区：
文献类型：
--
作者：
Cunliffe, NA;Gondwe, JS;Hart, CA
背景轮状病毒是幼儿严重腹泻的重要原因。我们研究了艾滋病毒感染的影响轮状病毒胃肠炎的介绍和结果Malawian children.Methods儿童年龄小于5岁的急性胃肠炎在伊丽莎白女王中央医院在布兰太尔从1997年7月，1999年6月，被招募。患有轮状病毒腹泻的儿童，无论是否感染艾滋病毒，在出院后随访长达4周。轮状病毒疾病的严重程度（20分），轮状病毒脱落的持续时间，轮状病毒的血清反应进行了比较HIV感染和HIV未感染的children.Findings 786住院患者（中位年龄8个月，其中271 [34%]人是HIV-1感染）和400门诊患者（中位年龄9个月，其中65 [16%]人是HIV感染）入组。在HIV感染儿童中检出轮状病毒的频率（30%）低于未感染HIV儿童（41%）（相对危险度0.71 [95%CI 0.53-0.87]，p=0.0007）。有和没有HIV感染的住院儿童的轮状病毒疾病严重程度没有差异，但HIV感染儿童在随访期间死亡的可能性（11/50 [22%]）高于HIV未感染儿童（0/61，p
Background Rotaviruses represent important causes of severe diarrhoea in early childhood. We examined the effect of HIV infection on the presentation and outcome of rotavirus gastroenteritis in Malawian children.Methods Children younger than 5 years who were treated for acute gastroenteritis at the Queen Elizabeth Central Hospital in Blantyre from July, 1997, to June, 1999, were enrolled. Children with rotavirus diarrhoea, with and without HIV infection, were followed up for up to 4 weeks after hospital discharge. Rotavirus disease severity (assessed with a 20-point score), duration of rotavirus shedding, and seroresponse to rotavirus were compared between HIV-infected and HIV-uninfected children.Findings 786 inpatients (median age 8 months, 271 [34%] of whom were HIV-1-infected) and 400 outpatients (median age 9 months, 65 [16%] of whom were HIV-infected) were enrolled. Rotavirus was detected less frequently among HIV-infected children (102 of 336 [30%]) than among HIV-uninfected children (348 of 850 [41%], (relative risk 0.71 [95% CI 0.53-0.87], p=0.0007). There were no differences in rotavirus disease severity for hospitalised children with and without HIV infection, but HIV-infected children were more likely to die during follow-up (11/50 [22%]) than HIV-uninfected children (0/61, p