[Extraction techniques for analysis of venlafaxine and its metabolites in biological matrices].
[Extraction techniques for analysis of venlafaxine and its metabolites in biological matrices].
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发表时间：
2013-09
影响因子：
1.7
通讯作者：
E. Dziurkowska;M. Wesołowski
中科院分区：
文献类型：
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作者：
E. Dziurkowska;M. Wesołowski
文拉法辛（Venlafaxine，VEN）是20世纪90年代引入治疗的最常用的抗抑郁药之一。建议监测其在生物体中的浓度，特别是在患者患有其他疾病并使用不同药物治疗的情况下，这可能会干扰VEN。用于测定VEN水平的最常用的诊断材料是血液。本研究是审查实际报告的方法提取VEN及其代谢产物从血液和其他人类诊断材料，如唾液和尿液，也从动物组织。介绍了经典的提取方法，如液-液萃取法和固相萃取法。并对液相微萃取法和浊点萃取法进行了改进。根据文献，可以说，当使用液-液萃取时，获得了VEN及其主要代谢产物O-去甲基文拉法辛的最佳回收率。新的、改进的提取方法具有成本效益，因为减少了溶剂的使用，而且诊断材料的体积也较小，但分析结果，特别是分析物的回收率，低于传统提取方法。
Venlafaxine (VEN), which was introduced into therapy in 1990s is one of the most often used antidepressants. The monitoring of its concentration in the organism is recommended, particularly in the case when a patient suffers of others illnesses and is treated with different drugs, which can interfere with VEN. The most popular diagnostic material for the determination of VEN level is blood. The present study is the review of actual reports on the methods of extraction of VEN and its metabolite from blood and other human diagnostic materials, like saliva and urine, and also from animals tissues. The paper shows the classic extraction methods, such as liquid-liquid extraction and solid-phase extraction. It also contains the modifications of these methods such as liquid-phase microextraction and cloud point extraction. According to the literature it can be stated that the best recovery of VEN and its main metabolite, O-demethylvenlafaxine, was obtained when the liquid-liquid extraction was used. The new, modified methods of extraction, are cost-effective, owing to the reduced use of solvents and also smaller volume of diagnostic material, but the results of the analysis, especially the recovery of the analytes, were lower than those obtained by classic methods of extraction.