Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds
Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds
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DOI：
10.1093/jn/136.3.864s
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发表时间：
2006-03-01
影响因子：
4.2
通讯作者：
Rivlin, RS
中科院分区：
文献类型：
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作者：
El-Bayoumy, K;Sinha, R;Rivlin, RS
早在公元前1550年，埃及人就意识到大蒜作为一种治疗各种疾病的药物的好处。许多流行病学研究支持大蒜和相关的大蒜食物对某些人类癌症的保护作用。天然大蒜和施硒栽培的大蒜在实验室动物身上已被证明在预防癌症方面具有保护作用。某些有机硒化合物及其硫磺类似物已在植物中被鉴定。对本实验室合成的有机硒化合物及其硫磺类似物的化学预防效果进行了比较。二烯丙基硒对7，12-二甲基苯并[a]菲(DMBA)诱导的大鼠乳腺癌的保护作用至少是二烯丙基硫化物的300倍。此外，亚硒酸苄酯还能抑制DMBA诱导的大鼠乳腺癌和偶氮甲烷诱导的大鼠结肠癌以及苯并[a]芘诱导的小鼠前胃肿瘤的发展。硫磺类似物硫氰酸苄酯在相同的实验条件下没有影响。此外，我们还发现，1，4-亚甲基双(亚甲基)硒氰酸酯显著抑制DMBA-DNA加合物的形成，并抑制DMBA诱导的乳腺癌的发生，而不是其硫磺类似物。总而言之，这些结果表明，结构独特的有机硒化合物在癌症化学预防方面优于相应的硫磺类似物。此外，合成的芳香族硒氰酸酯是比自然产生的硒氨基酸更有效的癌症化学预防药物。由于植物能够以类似于硫同化途径的方式利用硒，因此未来的研究应该着眼于确定在适当的条件下，这些有效的抗癌化学预防合成的硒化合物是否可以用大蒜和相关的大蒜食品来合成。
As early as 1550 B.C., Egyptians realized the benefits of garlic as a remedy for a variety of diseases. Many epidemiological studies support the protective role of garlic and related allium foods against the development of certain human cancers. Natural garlic and garlic cultivated with selenium fertilization have been shown in laboratory animals to have protective roles in cancer prevention. Certain organoselenium compounds and their sulfur analogs have been identified in plants. Organoselenium compounds synthesized in our laboratory were compared with their sulfur analogs for chemopreventive efficacy. Diallyl selenide was at least 300-fold more effective than diallyl sulfide in protecting against 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary adenocarcinomas in rats. In addition, benzyl selenocyanate inhibited the development of DMBA-induced mammary adenocarcinomas and azoxymethane-induced colon cancer in rats and benzo[a]pyrene-induced forestomach tumors in mice. The sulfur analog, benzyl thiocyanate, had no effect under the same experimental conditions. Furthermore, we showed that 1,4-phenylenebis(methylene)selenocyanate, but not its sulfur analog, significantly inhibited DMBA-DNA adduct formation and suppressed DMBA-induced mammary carcinogenesis. Collectively, these results indicate that structurally distinctive organoselenium compounds are superior to their corresponding sulfur analogs in cancer chemoprevention. Additionally, synthetic aromatic selenocyanates are more effective cancer chemopreventive agents than the naturally occurring selenoamino acids. Because plants are capable of utilizing selenium in a manner similar to that in sulfur assimilation pathways, future studies should aim at determining whether, under appropriate conditions, these potent cancer chemopreventive synthetic selenium compounds can be synthesized by garlic and related allium foods.