Aldosterone stimulates the proliferation of uterine leiomyoma cells
Aldosterone stimulates the proliferation of uterine leiomyoma cells
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DOI：
10.3109/09513590903511521
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发表时间：
2010-05-01
影响因子：
2
通讯作者：
Kimura, Tadashi
中科院分区：
文献类型：
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作者：
Isobe, Aki;Takeda, Takashi;Kimura, Tadashi
研究设计.本研究旨在探讨醛固酮在ELT-3平滑肌瘤细胞增殖中的作用。证实了醛固酮诱导ELT-3平滑肌瘤细胞增殖和盐皮质激素受体（MR）的表达。用MR阻断剂螺内酯或依普利酮预孵育细胞有效地抑制了醛固酮诱导的和血管紧张素II（Ang II）诱导的细胞增殖。醛固酮治疗可增加血管紧张素Ⅱ 1型受体mRNA水平。这些体外实验结果表明，血管紧张素II和醛固酮诱导的平滑肌瘤细胞增殖的复杂调节的存在。
Study design. This study investigated the potential role of aldosterone in the proliferation of ELT-3 leiomyoma cells.Results. Aldosterone-induced ELT-3 leiomyoma cell proliferation and the expression of mineralocorticoid receptor (MR) were confirmed. Pre-incubating the cells with the MR blockers spironolactone or eplerenone effectively repressed aldosterone-induced and angiotensin II (Ang II)-induced cell proliferation. Treatment of aldosterone increased the levels of Ang II type-1 receptor mRNA.Conclusion. These experimental findings in vitro show the presence of complex regulation of Ang II and aldosterone induced leiomyoma cell proliferation.