Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.
Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.
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DOI：
10.1161/circulationaha.108.772715
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发表时间：
2008-09-09
期刊：
影响因子：
37.8
通讯作者：
Lathrop DA
中科院分区：
文献类型：
--
作者：
Rudy Y;Ackerman MJ;Bers DM;Clancy CE;Houser SR;London B;McCulloch AD;Przywara DA;Rasmusson RL;Solaro RJ;Trayanova NA;Van Wagoner DR;Varró A;Weiss JN;Lathrop DA
美国国家心脏、肺和血液研究所(NHLBI)于2007年8月20日和21日在华盛顿特区召开了一次由心脏病学家、心脏电生理学家、细胞生物物理学家和计算模型师组成的研讨会，就开发综合方法阐明人类心脏功能所需的新研究方向向NHLBI提供建议。该研讨会致力于确定使用非人类动物物种的数据来阐明人类机电功能/活动的局限性，并确定需要从人类心脏组织中获得关于离子通道动力学、钙处理和细胞内/细胞外环境动态变化的哪些具体信息，以开发更可靠的人类心脏机电活动计算模型。本文总结了研讨会关于下列主题的讨论和建议：(1)动物模型的局限性和与人类电生理学的差异，(2)在全细胞电生理学的背景下对离子通道结构/功能进行建模，(3)兴奋-收缩耦合和调节通路，(4)对人类机电活动的全心模拟，以及(5)目前需要哪些人体数据以及如何获得这些数据。这些建议可以在NHLBI的网站上找到，网址是http://www.nhlbi.nih.gov/meetings/workshops/electro.htm.
The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of cardiologists, cardiac electrophysiologists, cell biophysicists, and computational modelers on August 20 and 21, 2007, in Washington, DC, to advise the NHLBI on new research directions needed to develop integrative approaches to elucidate human cardiac function. The workshop strove to identify limitations in the use of data from nonhuman animal species for elucidation of human electromechanical function/activity and to identify what specific information on ion channel kinetics, calcium handling, and dynamic changes in the intracellular/extracellular milieu is needed from human cardiac tissues to develop more robust computational models of human cardiac electromechanical activity. This article summarizes the workshop discussions and recommendations on the following topics: (1) limitations of animal models and differences from human electrophysiology, (2) modeling ion channel structure/function in the context of whole-cell electrophysiology, (3) excitation–contraction coupling and regulatory pathways, (4) whole-heart simulations of human electromechanical activity, and (5) what human data are currently needed and how to obtain them. The recommendations can be found on the NHLBI Web site at http://www.nhlbi.nih.gov/meetings/workshops/electro.htm.