Intergenic exchange maintains identity between two human lambda light chain immunoglobulin gene intron sequences.
Intergenic exchange maintains identity between two human lambda light chain immunoglobulin gene intron sequences.
复制标题
基因间交换维持两个人λ轻链免疫球蛋白基因内含子序列之间的同一性。
DOI：
10.1093/nar/16.7.2959
复制
发表时间：
1988
影响因子：
14.9
通讯作者：
Blomberg,BB
中科院分区：
文献类型：
--
作者：
Udey,JA;Blomberg,BB
提出了人 λ 轻链免疫球蛋白基因座中基因转换或不等双交换的证据。 J2C2-J3C3内含子交叉杂交的高水平、Jλ2和Jλ3编码和内含子序列的同一性、Cλ2和Cλ3编码区之间存在多个碱基差异、以及正常基因库中未转化和转化的所有基因的存在，表明重组事件导致Jλ2编码和内含子序列转化为Jλ3及其侧翼序列。基因间交换，例如本文所述的交换，可以提供一种维持人类 lambda 基因家族重复成员之间的序列同质性和功能性的机制。
Evidence for gene conversion or unequal double crossover in the human λ light chain imunoglobulin locus is presented. The high level of J2C2-J3C3 Intron cross-hybridization, the identity of the Jλ2 and Jλ3 coding and intron sequences, the presence of multiple base differences between the Cλ2 and Cλ3 coding regions, and the presence of both the unconverted and converted all eles in the normal gene pool, suggest that a recombinational event has resulted in the conversion of the Jλ2 coding and intron sequences to those of Jλ3 and Its flanking sequences. Intergenic exchanges, such as the one described here, may provide a mechanism to maintain sequence homogeneity and functionality among the duplicated members of the human lambda gene family.