PREFERENTIAL EXPRESSION OF CATFISH LIGHT CHAIN IMMUNOGLOBULIN ISOTYPES IN ANTI‐DINITROPHENYL ANTIBODIES

PREFERENTIAL EXPRESSION OF CATFISH LIGHT CHAIN IMMUNOGLOBULIN ISOTYPES IN ANTI‐DINITROPHENYL ANTIBODIES
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抗二硝基苯基抗体中鲶鱼轻链免疫球蛋白同种型的优先表达

DOI:
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发表时间:
1986
期刊:
European journal of immunogenetics
影响因子:
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通讯作者:
C. J. Lobb
C. J. Lobb
中科院分区:
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文献类型:
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作者:
C. J. Lobb

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以往的研究表明斑点叉尾鱼的免疫球蛋白含有两种不同类型的轻链。这些不同的轻链,标记为F和G,让人想起高等动物的κ和λ轻链。本研究旨在确定在抗二硝基苯基抗体的免疫应答过程中,是否存在轻链的优势表达。结果表明,虽然初次免疫后早期(1-2周)产生的抗体含有大量的G轻链(∼为20%),但在以后(3周至1年)产生的抗体绝大多数(∼为90%)是F亚型。因此,鱼类和高等脊椎动物在免疫反应中可以表达不同类型的抗体。
Previous studies indicated that immunoglobulins of the channel catfish, Ictalurus punctatus, contained two distinct isotypes of light chains. These different light chains, designated F and G, are reminiscent of κ and λ light chains of higher animals. This study was undertaken to establish whether or not there was preferential expression of one of the light chains in antibodies induced to the dinitrophenyl moiety during the course of the catfish humoral antibody response. The results indicated that, although antibody produced very early (1‐2 weeks) after primary immunization contained significant amounts (∼20%) of G light chains, the vast majority (∼90%) of antibody produced later (3 weeks through 1 year) was of the F isotype. Thus fish, as well as higher vertebrates, can express different isotypes of antibody during the immune response.
二硝基苯基抗原抗体中的优先独特型-同种型关联。
DOI: --
发表时间: 1982
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Scott,MG;Fleischman,JB
通讯作者: Fleischman,JB
小鼠重链可变区标记 J606-GAC 不限于特定的 B 细胞同种型或亚群。
DOI: --
发表时间: 1984
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Basta,P;Briles,DE
通讯作者: Briles,DE
DOI: --
发表时间: 1983
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Fulton,RJ;Nahm,MH;Davie,JM
通讯作者: Davie,JM
单克隆抗体识别小鼠 IgD 和 IgM 的同种异型特异性。
DOI: --
发表时间: 1984
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Stall,AM;Loken,MR
通讯作者: Loken,MR