Dynorphin Immunoreactive Fibers Contact GnRH Neurons in the Human Hypothalamus
Dynorphin Immunoreactive Fibers Contact GnRH Neurons in the Human Hypothalamus
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DOI：
10.1177/1933719109336619
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发表时间：
2009-08-01
影响因子：
2.9
通讯作者：
Lehman, Michael
中科院分区：
文献类型：
--
作者：
Dahl, Stephanie K.;Amstalden, Marcel;Lehman, Michael
强啡肽是一种内源性阿片肽，在其他物种中介导孕酮阴性的反馈油促性腺激素释放激素（GnRH）神经元。强啡肽在人体中的作用尚不清楚。本研究的目的是确定强啡肽纤维是否勇敢地与GnRH神经元密切接触。应用Dial标记免疫细胞化学技术对人死后下丘脑组织进行染色。多数GnRH神经元（87.5%）与强啡肽纤维有密切接触，多个密切接触者常见（62.5%）。密切接触者下丘脑和视前区病变分布无区域差异。与细胞体相比，油轮胎GnRH树突识别出更多的密切接触者（P <0.001），但当校正长度时，这种差异并不显著。总之，强啡肽纤维与人类GnRH神经元形成密切联系。这种神经解剖学证据可能表明，强啡肽对人类的GnRH调节具有影响，正如在其他物种中所看到的那样。
Dynorphin, an endogenous opioid peptide, mediates progesterone-negative,feedback oil gonadotropin-releasing hormone (GnRH) neurons in other species. The role of dynorphin in humans is unclear. The objective of this study was to determine if dynorphin fibers brave close contacts with GnRH neurons ill humans. Dial-label immunocytochemistry was performed oil postmortem human hypothalamic tissue. The majority, of GnRH neurons, 87.5%, had close contacts with dynorphin fibers and multiple close contacts were common, 62.5%. There were no regional differences between the hypothalamus and preoptic area ill tire distribution of close contacts. More close contacts were identified oil tire GnRH dendrites compared to the cell bodies (P < .001), bill this difference was not significant when corrected for length. In conclusion, dynorphin fibers,form close contacts with GnRH neurons ill humans. This neuroanatomical evidence may suggest that dynorphin has effects oil GnRH regulation ill humans as seen ill other species.