The rachitic tooth: Refining the use of interglobular dentine in diagnosing vitamin D deficiency
The rachitic tooth: Refining the use of interglobular dentine in diagnosing vitamin D deficiency
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DOI：
10.1016/j.ijpp.2018.07.001
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发表时间：
2018-09-01
影响因子：
1.2
通讯作者：
Brickley, Megan
中科院分区：
文献类型：
--
作者：
D'Ortenzio, Lori;Kahlon, Bonnie;Brickley, Megan
目的：本研究为牙本质中IGD与其他天然存在的微结构的鉴别提供了指导。球间牙本质（IGD）最近已被链接到维生素D，钙，磷途径提供了一个有价值的方法来研究维生素D缺乏症的考古个体，但不是所有的牙本质缺陷IGD.Methods：牙科文献和牙齿组织学病例收集的详细审查已知的生活和考古个体纳入解释。结果：对牙本质的研究表明，IGD可能与维生素D缺乏无关。结论：我们得出结论，在评估低级别IGD时需要谨慎，因为它可能被错误识别。知识贡献：回顾和吸收的信息有助于完善IGD作为生物标志物的作用，特别是在不太严重的维生素D缺乏症的情况下，通过提供明确的指导。从早期的实验工作的信息是有限的，直到最近的理解维生素D和缺乏这种激素原是restricted.Suggestions进一步研究：进一步的数据可以收集从生活的个人与已知的生物/医学信息。
Purpose: This study provides guidelines on how IGD can be differentiated from other microstructures that naturally occur in dentine. Interglobular dentine (IGD) has recently been linked to disruption in vitamin D, calcium, and phosphorous pathways offering a valuable method to investigate vitamin D deficiency in archaeological individuals, but not all dentine defects are IGD.Methods: A detailed review of dental literature and dental histology cases gathered from known living and archaeological individuals were incorporated into interpretations.Results: Investigation of tooth dentine revealed that there can be instances where IGD is not linked to vitamin D deficiency. Information on how to differentiate different forms of defects in dentine were identified.Conclusions: We conclude that caution is required when evaluating low-grade IGD, as it may be misidentified.Contribution to knowledge: Information reviewed and assimilated contributes to refining the role of IGD to act as a biological marker, particularly in less severe cases of vitamin D deficiency through provision of clear guidance.Limitations of this study: Information from earlier experimental work is limited and until recently understanding of vitamin D and deficiency of this pro-hormone was restricted.Suggestions for further research: Further data could be gathered from living individuals with known biological/medical information.