The Influence of Pregnancy and Menstruation on the Deterioration of Atopic Dermatitis Symptoms
The Influence of Pregnancy and Menstruation on the Deterioration of Atopic Dermatitis Symptoms
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DOI：
10.5021/ad.2010.22.2.180
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发表时间：
2010-05-01
影响因子：
1.6
通讯作者：
Lee, Kwang Hoon
中科院分区：
文献类型：
--
作者：
Cho, Suhyun;Kim, Hee Jung;Lee, Kwang Hoon
背景：女性特应性皮炎（AD）患者经常经历与妊娠或月经周期相关的皮肤恶化。目的：我们想要确定女性AD患者中与妊娠和月经周期相关的症状加重的患病率。方法：选取100例女性AD患者进行访谈。回顾性分析患者的总IgE水平和湿疹面积及严重程度指数评分。结果：97例患者回答了问卷，其中23例患者至少完成了1次妊娠。在23名怀孕妇女中，14名（61%）在怀孕期间注意到其临床症状恶化。在97名女性患者中，31名（32%）患者注意到其AD恶化与月经周期有关。对内因型AD患者亚组中，与妊娠相关的症状加重发生率明显高于外因型AD患者（p = 0.048）。结论：97例女性患者中有45例（46%）回答在妊娠期或与月经周期有关的AD病情恶化，提示激素对AD临床表现的影响。（Ann Dermatol 22(2) 180，类似于185,2010）
Background: Female patients with atopic dermatitis (AD) often experience cutaneous deterioration associated with their pregnancy or menstrual cycle. Objective: We wanted to determine the prevalence of symptom aggravation as related to pregnancy and the menstrual cycle in female patients with AD. Methods: One hundred female patients with AD were included in the study and interviews were performed. The total IgE level and the Eczema Area and Severity Index score of the patients were retrospectively reviewed. Results: Ninety seven patients replied the questionnaire, and among them, 23 patients had completed at least 1 pregnancy. Among the 23 women who experienced pregnancy, 14 (61%) had noticed deterioration of their clinical symptoms during pregnancy. Of the 97 females, 31 (32%) patients had noticed deterioration of their AD as related to their menstrual cycle. For the patients who were sub-grouped as the intrinsic type of AD, the prevalence of symptom aggravation as related to pregnancy was significantly higher as compared to that of the extrinsic type of AD patients (p = 0.048). Conclusion: Of the 97 patients, 45 (46%) females answered that they have experienced deterioration of AD during pregnancy or in relation to their menstrual cycle, and this suggests the relation of a hormonal influence on the clinical manifestations of AD. (Ann Dermatol 22(2) 180 similar to 185, 2010)