Rates and characteristics of SARS-CoV-2 infection in persons with hepatitis C virus infection
Rates and characteristics of SARS-CoV-2 infection in persons with hepatitis C virus infection
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DOI：
10.1111/liv.14681
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发表时间：
2020-10-10
影响因子：
6.7
通讯作者：
Yan, Peng
中科院分区：
文献类型：
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作者：
Butt, Adeel A.;Yan, Peng
SARS-CoV-2感染率和肝纤维化分期对丙型肝炎病毒（HCV）感染者感染率的影响尚不清楚。方法我们回顾性分析了HCV感染退伍军人的电子检索队列（ERCHIVES），这是一个建立良好的HCV感染退伍军人护理数据库。我们排除了FI B-4评分缺失的患者和HIV或B型肝炎病毒合并感染的患者。我们确定了检测的人数，SARS-CoV-2检测阳性的比例以及年龄和肝纤维化阶段的感染率。结果在172,235例HCV感染者中，14,305例（8.3%）检测出SARS-CoV-2感染，892例（6.2%）检测出阳性。SARS-CoV-2感染者年龄较大，更可能是黑人（55.2% vs 37.8%），肥胖（体重指数>30 kg/m2）36.2% vs 29.7%），并患有糖尿病或中风（所有比较P <0.0001）。两组的平均FIB-4评分和肝硬化患者比例（基于FIB-4 > 3.25）相似。黑人（88.4; 95%CI 81.1，96.2）的发病率/1，000名受试者远高于白人（37.5; 95%CI 33.1，42.4），但肝硬化患者的发病率/1，000名受试者相似（FIB-4 > 3.25）。未接受HCV治疗的患者与接受或未接受持续病毒学应答治疗的患者的发生率也相似。结论HCV感染者的检测率很低。感染者更有可能是黑人，有较高的体重指数和糖尿病或中风。肝纤维化的程度似乎对感染率没有影响。
Background Rate of SARS-CoV-2 infection and impact of liver fibrosis stage upon infection rates in persons with hepatitis C virus (HCV) infection are unknown. Methods We retrospectively analysed the Electronically Retrieved Cohort of HCV Infected Veterans (ERCHIVES), a well-established database of HCV-infected Veterans in care. We excluded those with missing FIB-4 score and those with HIV or hepatitis B virus co-infection. We determined the number of persons tested, proportion who tested positive for SARS-CoV-2 and the infection rate by age and liver fibrosis stage. Results Among 172,235 persons with HCV, 14,305 (8.3%) were tested for SARS-CoV-2 infection and 892 (6.2%) tested positive. Those with SARS-CoV-2 infection were older, more likely to be Black (55.2% vs 37.8%), obese (body mass index >30 kg/m(2)36.2% vs 29.7%) and have diabetes or stroke (P < .0001 for all comparisons). Mean FIB-4 scores and proportion of persons with cirrhosis (based on a FIB-4 > 3.25) were similar in both groups. Incidence rate/1,000 tested persons was much higher among Blacks (88.4; 95% CI 81.1, 96.2) vs Whites (37.5; 95% CI 33.1, 42.4) but similar among those with cirrhosis (FIB-4 > 3.25). The rates were also similar among those who were untreated for HCV vs those treated with or without attaining a sustained virologic response. Conclusions Testing rates among persons with HCV are very low. Persons with infection are more likely to be Black, have a higher body mass index and diabetes or stroke. The degree of liver fibrosis does not appear to have an impact on infection rate.