Relationships between neuropsychological test performance and event-related potentials in alcoholic and nonalcoholic samples.
Relationships between neuropsychological test performance and event-related potentials in alcoholic and nonalcoholic samples.
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酒精和非酒精样本中神经心理学测试表现与事件相关电位之间的关系。
DOI：
10.1111/j.1530-0277.1990.tb01239.x
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Williams,HL
中科院分区：
文献类型：
--
作者：
Parsons,OA;Sinha,R;Williams,HL
事件相关电位和非同时测量的神经心理测试表现是否相关？清醒的男性和女性中年酗酒者和同龄人对照组进行了一项“古怪”事件相关电位（ERP）任务，几小时后，进行了一系列神经心理学（NP）测试。酗酒者在NP测试中的表现明显低于对照组。男性酗酒者有显着改变ERP反应（N1，NdA，P3振幅），但女性酗酒者没有任何ERP变量从控制。ERP和NP措施之间存在一些显着的相关性。最一致的发现是男性和女性酗酒者以及男性酗酒者的感知-运动（PM）测试与Pz处的P3振幅之间的正相关性，PM测试与Pz处的P3潜伏期之间的负相关性，与帕金森患者中观察到的结果相似。在家族史阳性的酗酒者中，显著相关性最多。结果导致两个结论：第一，格兰特的假设，清醒的酗酒者可能会表现出中间持续时间的有机精神障碍的支持;第二，由于缺乏ERP的女性差异，ERP措施不应被视为是因果关系的NP性能。
Are event‐related potentials and nonconcurrently measured neuropsychological test performance correlated? Sober male and female middle‐aged alcoholics and peer controls were administered an “oddball” event‐related potential (ERP) task and several hours later, a battery of neuropsychological (NP) tests. Alcoholics performed significantly poorer than controls on NP tests. Male alcoholics had significantly altered ERP responses (N1, NdA, and P3 amplitudes) but female alcoholics did not differ on any ERP variables from controls. A number of significant correlations between ERP and NP measures were present. The most consistent findings were positive correlations between perceptual‐motor (PM) tests and the P3 amplitude at Pz in both male and female alcoholics and in male alcoholics, a negative correlation between PM tests and P3 latency at Pz, findings similar to those seen in Parkinson patients. Significant correlations were most numerous in family history positive alcoholics. The results lead to two conclusions: first, Grant's postulation that sober alcoholics may manifest an intermediate duration organic mental disorder is supported; second, given the lack of ERP differences in the females, ERP measures should not be considered as being causally related to NP performance.