Cytomegalovirus DNA is highly prevalent in the blood of patients with asthma and is associated with age and asthma traits
Cytomegalovirus DNA is highly prevalent in the blood of patients with asthma and is associated with age and asthma traits
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DOI：
10.1111/all.13233
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发表时间：
2017-12-01
期刊：
影响因子：
12.4
通讯作者：
Paradowska, E.
中科院分区：
文献类型：
--
作者：
Kowalski, M. L.;Wardzynska, A.;Paradowska, E.
巨细胞病毒（CMV）IgG抗体与炎症和免疫衰老有关。我们的目的是评估成人和老年支气管哮喘患者血液中CMV DNA的存在，以确定CMV DNA血症与哮喘和哮喘特征的潜在关联。招募了85名老年哮喘患者，74名年轻哮喘患者和114名年龄匹配的对照组。10.7%的哮喘患者用Artus试剂盒检测到CMV DNA，而对照组均为阴性。第二次检测在41.5%的哮喘患者和13.3%的对照组中鉴定出CMV DNA（P <0.001）。CMV DNA的存在与哮喘风险增加相关，CMV DNA拷贝数与一些哮喘特征相关，包括呼吸参数和呼出气一氧化氮。我们的结论是CMV感染与哮喘有关，并可能有助于哮喘炎症的发病机制。
Cytomegalovirus (CMV) IgG antibodies have been associated with inflammaging and immunosenescence. We aimed to assess the presence of CMV DNA in the blood of adult and elderly patients with bronchial asthma to establish potential association of CMV DNAemia with asthma and asthma characteristics. Eighty-five elderly asthmatics, 74 younger asthma patients, and 114 age-matched controls were recruited. The CMV DNA was detected using commercial artus assay in 10.7% of asthma patients, but was negative in all control individuals. The secondary assay identified CMV DNA in 41.5% of asthmatics and 13.3% of control subjects (P < .001). Presence of CMV DNA was associated with an increased risk of asthma and CMV DNA copy numbers correlated with some asthma traits, including respiratory parameters and exhaled breath nitric oxide. We conclude that CMV infection is associated with asthma and may contribute to the pathogenesis of asthmatic inflammation.