Aberrant Epigenetic Regulation in the Pathogenesis of Systemic Lupus Erythematosus and Its Implication in Precision Medicine
Aberrant Epigenetic Regulation in the Pathogenesis of Systemic Lupus Erythematosus and Its Implication in Precision Medicine
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系统性红斑狼疮发病机制中的异常表观遗传调控及其在精准医学中的意义
DOI：
10.1159/000448793
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发表时间：
2016
影响因子：
1.7
通讯作者：
Lu Qianjin
中科院分区：
文献类型：
--
作者：
Zhan Yi;Guo Yu;Lu Qianjin
系统性红斑狼疮（SLE）复杂的免疫失调在过去的几十年中取得了很大的进展，但寻求有效治疗SLE的努力被证明是徒劳的。系统性红斑狼疮的病因是多种遗传和表观遗传因素相互作用的结果。多个基因位点易患疾病的易感性，并通过性别，激素和下丘脑-垂体-肾上腺轴介导的表观遗传修饰的相互作用，使这种疾病的易感性和表现复杂化。最后，某些环境和心理因素可能通过表观遗传机制引发疾病。在这篇综述中，我们总结和讨论了最近的表观遗传学研究的SLE，并提出了个性化的方法来解剖疾病的发病和治疗或精准医学。我们推测，在未来，基于表观遗传和遗传信息的精准医学可能有助于指导更有效的靶向治疗干预。
Great progress has been made in the last decades in understanding the complex immune dysregulation in systemic lupus erythematosus (SLE), yet the efforts to pursue an effective treatment of SLE proved to be futile. The pathoetiology of SLE involves extremely complicated and multifactorial interaction among various genetic and epigenetic factors. Multiple gene loci predispose to disease susceptibility, and the interaction with epigenetic modifications mediated through sex, hormones, and the hypothalamo-pituitary-adrenal axis complicates susceptibility and manifestations of this disease. Finally, certain environmental and psychological factors probably trigger the disease via epigenetic mechanisms. In this review, we summarize and discuss recent epigenetic studies of SLE and suggest a personalized approach to the dissection of disease onset and therapy or precision medicine. We speculate that in the future, precision medicine based on epigenetic and genetic information could help guide more effective targeted therapeutic intervention.