MAJOR TRANQUILIZERS CAN BE DISTINGUISHED FROM MINOR TRANQUILIZERS ON THE BASIS OF EFFECTS ON MARBLE BURYING AND SWIM-INDUCED GROOMING IN MICE
MAJOR TRANQUILIZERS CAN BE DISTINGUISHED FROM MINOR TRANQUILIZERS ON THE BASIS OF EFFECTS ON MARBLE BURYING AND SWIM-INDUCED GROOMING IN MICE
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DOI：
10.1016/0014-2999(86)90051-8
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发表时间：
1986-07-31
影响因子：
5
通讯作者：
LLOYD, KL
中科院分区：
文献类型：
--
作者：
BROEKKAMP, CL;RIJK, HW;LLOYD, KL
比较了精神药物对小鼠梳理和掩埋的影响。玻璃弹珠引起埋地行为，游泳3分钟后观察梳理。具有轻微镇静作用的化合物，如地西泮、氯二氮环氧化物、氟硝西泮、氯硝西泮、甲丙酸酯和乙醇，对减少埋藏比梳理更有效。具有抗胆碱能作用的药物，如东莨菪碱和阿托品，对埋葬也更有效。一些抗精神病药物，如氟哌啶醇、氯丙嗪、奋那嗪和三氟哌啶醇，比掩埋更有效地减少梳理。氯氮平、硫硝嗪、苯海拉明、丙咪嗪、米安色林和阿波吗啡均有非选择性抑制作用。结论是，尽管存在一定的局限性，但所描述的埋藏-梳理测试提供了一种简单的工具，用于识别新化合物作为潜在的主要或次要镇静剂。
The effects of psychotropic compounds on grooming and burying were compared in mice. Burying behaviour was provoked by glass marbles and grooming was observed after 3 min swimming. Compounds with minor tranquilizing properties, such as diazepam, chlordiazepoxide, flunitrazepam, clonazepam, meprobamate and ethyl alcohol, were more effective in reducing burying than grooming. Drugs with an anticholinergic effect, e.g. scopolamine and atropine were also more effective against burying. A number of neuroleptic drugs, such as haloperidol, chlorpromazine, perphenazine and trifluperidol reduced grooming more effectively than burying. Non-selective inhibitory effects were observed with clozapine, thioridazine, diphenhydramine, imipramine, mianserin and apomorphine. It is concluded that, with certain limitations, the burying-grooming test described offers a simple tool for identifying novel compounds as potential major or minor tranquilizers.