Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh
Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh
复制标题
DOI：
10.1002/dvdy.21237
复制
发表时间：
2007-08-01
影响因子：
2.5
通讯作者：
Martinez, S.
中科院分区：
文献类型：
--
作者：
Gimeno, L.;Martinez, S.
成纤维细胞生长因子（Fgfs）是一个信号分子家族，在发育过程中发挥重要作用。我们研究了Fgf15在发育中的小鼠大脑中的表达模式。Fgf19是FGF家族的另一个成员，被认为是小鼠和大鼠Fgf15的鸡和人同源基因。本研究比较了鸡Fgf19和小鼠Fgf15在神经发育过程中的表达模式。与Fgf15不同，Fgf19在峡鼻翼板、间脑和中脑基底旁板、后脑基底板以及丘脑内限定带（zli）中表达。此外，我们探索了Fgf19分别与地峡和zli组织者信号分子Fgf8和Shh之间的调控。考虑到Fgf19在人类和雏鸡中发挥类似作用的可能性，这一发现可以解释在Shh通路受影响的模型和疾病中，人类和小鼠间脑表型的显著差异。
Fibroblast growth factors (Fgfs) constitute a family of signaling molecules that play essential roles in development. We have studied the expression pattern of mouse Fgf15 in the developing brain. Fgf19 is another member of the FGF family that has been suggested as the chick and human ortholog of mouse and rat Fgf15. Here, we compare the expression pattern during neural development of chick Fgf19 with mouse Fgf15. Unlike Fgf15, Fgf19 presents an expression in the isthmic alar plate, diencephalic and mesencephalic parabasal plates, hindbrain basal plate, as well as in the zona limitans intrathalamica (zli). Moreover, we explored the regulation between Fgf19 and the signaling molecules of the isthmic and zli organizers: Fgf8 and Shh, respectively. Considering the possibility that Fgf19 plays a similar role in humans and chicks, this finding could explain the significant diencephalic phenotypic differences between humans and mice in models and diseases where the Shh pathway is affected.