Cellular regulation of prostaglandin H synthase catalysis.
Cellular regulation of prostaglandin H synthase catalysis.
复制标题
前列腺素 H 合酶催化的细胞调节。
DOI：
10.1016/s0014-5793(98)00657-7
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发表时间：
1998
期刊：
影响因子：
3.5
通讯作者：
Kulmacz,RJ
中科院分区：
文献类型：
--
作者：
Kulmacz,RJ
前列腺素是一组有效的生物活性脂质，由花生四烯酸或几种相关的多不饱和脂肪酸之一氧化产生。细胞前列腺素的生物合成受到严格的调控，其中很大一部分调控是在前列腺素H合成酶（PGHS）催化环加氧酶水平上进行的。PGHS的两种已知亚型具有不同的病理生理功能，其环加氧酶活性受不同的细胞控制。本文综述了细胞内区隔、辅助蛋白、花生四烯酸水平和过氧化氢活化剂对两种PGHS亚型的细胞催化控制的贡献。
Prostanoids are a group of potent bioactive lipids produced by oxygenation of arachidonate or one of several related polyunsaturated fatty acids. Cellular prostaglandin biosynthesis is tightly regulated, with a large part of the control exerted at the level of cyclooxygenase catalysis by prostaglandin H synthase (PGHS). The two known isoforms of PGHS have been assigned distinct pathophysiological functions, and their cyclooxygenase activities are subject to differential cellular control. This review considers the contributions to cellular catalytic control of the two PGHS isoforms by intracellular compartmentation, accessory proteins, arachidonate levels, and availability of hydroperoxide activator.