Control of parallel hippocampal output pathways by amygdalar long-range inhibition.
Control of parallel hippocampal output pathways by amygdalar long-range inhibition.
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DOI：
10.7554/elife.74758
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发表时间：
2021-11-30
期刊：
影响因子：
7.7
通讯作者：
MacAskill AF
中科院分区：
文献类型：
--
作者：
AlSubaie R;Wee RW;Ritoux A;Mishchanchuk K;Passlack J;Regester D;MacAskill AF
从基底杏仁核（BA）到腹侧海马体（vH）的投射可以提供关于习得关联的奖励或威胁性质的信息，以支持适当的目标导向和焦虑样行为。这种行为通过vH中多个平行的锥体神经元群的不同活动发生，这些神经元群投射到不同的下游目标，但BA输入的性质及其与这些群体的联系尚不清楚。利用通道视紫红质-2辅助的小鼠电路映射，我们发现BA对vH的输入包括兴奋性和抑制性投射。兴奋性输入专门针对BA和伏隔核的vH神经元，避免前额叶皮层的vH神经元，而抑制性输入优先针对BA的vH神经元。通过这种特定的连通性，BA抑制投射通过控制伏隔核vH神经元的活动来抑制位置值关联。我们的研究结果定义了从BA到vH的平行兴奋和抑制投射，可以支持目标导向行为。
Projections from the basal amygdala (BA) to the ventral hippocampus (vH) are proposed to provide information about the rewarding or threatening nature of learned associations to support appropriate goal-directed and anxiety-like behaviour. Such behaviour occurs via the differential activity of multiple, parallel populations of pyramidal neurons in vH that project to distinct downstream targets, but the nature of BA input and how it connects with these populations is unclear. Using channelrhodopsin-2-assisted circuit mapping in mice, we show that BA input to vH consists of both excitatory and inhibitory projections. Excitatory input specifically targets BA- and nucleus accumbens-projecting vH neurons and avoids prefrontal cortex-projecting vH neurons, while inhibitory input preferentially targets BA-projecting neurons. Through this specific connectivity, BA inhibitory projections gate place-value associations by controlling the activity of nucleus accumbens-projecting vH neurons. Our results define a parallel excitatory and inhibitory projection from BA to vH that can support goal-directed behaviour.