Maintenance of chromosome structure in Pseudomonas aeruginosa.
Maintenance of chromosome structure in Pseudomonas aeruginosa.
复制标题
铜绿假单胞菌染色体结构的维持。
DOI：
10.1111/1574-6968.12478
复制
发表时间：
2014
影响因子：
2.1
通讯作者：
Rybenkov,ValentinV
中科院分区：
文献类型：
--
作者：
Rybenkov,ValentinV
遗传信息的复制和分离是所有活细胞健康的核心活动。协调一致的机制已经进化，确保每个细胞染色体在每个细胞周期复制一次且仅复制一次，然后忠实地分离成子细胞。尽管存在显著的分类多样性，但这些机制在真细菌中基本上是保守的，尽管经常可以注意到物种特异性的区别。在这里，我们提供了一个关于铜绿假单胞菌染色体结构维持的知识现状的概述。我们专注于全球染色体组织及其在DNA复制和细胞分裂过程中的动态。特别强调的是对比这些活动在P。aerodyniae和其他细菌。在uniqueP.铜绿假单胞菌的特征是存在两个不同的自主复制序列和多个缩合酶，这表明存在新的调控机制。
Replication and segregation of genetic information are the activities central to the well-being of all living cells. Concerted mechanisms have evolved that ensure that each cellular chromosome is replicated once and only once per cell cycle and then faithfully segregated into daughter cells. Despite remarkable taxonomic diversity, these mechanisms are largely conserved across eubacteria, although species-specific distinctions can often be noted. Here, we provide an overview of the current state of knowledge about maintenance of the chromosome structure inPseudomonas aeruginosa. We focus on global chromosome organization and its dynamics during DNA replication and cell division. Special emphasis is made on contrasting these activities inP. aeruginosaand other bacteria. Among uniqueP. aeruginosa,features are the presence of two distinct autonomously replicating sequences and multiple condensins, which suggests existence of novel regulatory mechanisms.