THE EFFECTS OF ACETALDEHYDE AND ACROLEIN ON BLOOD-PRESSURE IN GUANETHIDINE-PRETREATED HYPERTENSIVE RATS
THE EFFECTS OF ACETALDEHYDE AND ACROLEIN ON BLOOD-PRESSURE IN GUANETHIDINE-PRETREATED HYPERTENSIVE RATS
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DOI：
10.1016/0041-008x(83)90115-1
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发表时间：
1983-01-01
影响因子：
3.8
通讯作者：
EGLE, JL
中科院分区：
文献类型：
--
作者：
GREEN, MA;EGLE, JL
本文研究了抗高血压药乙啶和两种具有拟交感神经活性的醛类化合物对自发性高血压大鼠（SHR）血压的相互作用。在乌拉坦麻醉下，静脉注射乙醛（3-40 mg/kg）给药于急性乙啶预处理（15 mg/kg）的SHR，引起增强的升压反应。当静脉注射给药的长期乙啶预处理的SHR，升压反应在低剂量和降压反应在高剂量。丙烯醛（0.05-0.5 mg/kg）在急性和慢性乙啶预处理的SHR中在低剂量下产生升压反应，在高剂量下产生降压反应。升压反应，特别是对乙醛的升压反应，可能是由于增大的酪胺可释放池、α-羟色胺的高反应性、以及α-羟色胺的高反应性。SHR肾上腺素能受体或乙啶抑制去甲肾上腺素重摄取。对高剂量醛类的降压反应可能归因于迷走神经刺激或直接血管舒张。醛和乙啶之间存在显著的相互作用，这可能对接受乙啶治疗高血压的人有影响，同时暴露于乙醇和烟草烟雾中的乙醛和相关化合物。
The interaction of the antihypertensive agent guanethidine and 2 aldehydes possessing sympathomimetic activity on the blood pressure of spontaneously hypertensive rats (SHR) was studied. Acetaldehyde, when administered i.v. to acutely guanethidine-pretreated (15 mg/kg) SHR under urethane anesthesia, caused a potentiated pressor response at 3-40 mg/kg. When administered i.v. to chronically guanethidine-pretreated SHR, a pressor response was noted at low doses and a depressor response at high doses. Acrolein (0.05-0.5 mg/kg) produced a pressor response at low doses and a depressor response at high doses in acutely and chronically guanethidine-pretreated SHR. Pressor responses, particularly to acetaldehyde, may have been due to an enlarged tyramine-releasable pool, hyperreactivity of .alpha.-adrenergic receptors of SHR or guanethidine inhibition of norepinephrine reuptake. Depressor responses to high doses of aldehydes may have been attributed to vagal stimulation or direct vasodilation. There was a significant interaction between the aldehydes and guanethidine, which may have implications for someone undergoing treatment with guanethidine for hypertension while being exposed to acetaldehyde and related compounds from ethanol and tobacco smoke.