Fetal alcohol exposure, iron-deficiency anemia, and infant growth
Fetal alcohol exposure, iron-deficiency anemia, and infant growth
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DOI：
10.1542/peds.2007-0151
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发表时间：
2007-09-01
期刊：
影响因子：
8
通讯作者：
Jacobson, Joseph L.
中科院分区：
文献类型：
--
作者：
Carter, R. Colin;Jacobson, Sandra W.;Jacobson, Joseph L.
目标。我们的目的是确定产前酒精暴露是否与婴儿缺铁性贫血发病率增加有关，并比较胎儿酒精暴露和缺铁性贫血对婴儿生长的影响。我们还测试了胎儿酒精暴露对生长的影响是否由缺铁性贫血介导或调节。南非开普敦有色人种（混合血统）社区的母亲所生的96名婴儿在产前被招募；42名母亲在怀孕期间大量饮酒，54名母亲戒酒或少量饮酒。在出生、6.5和12个月时评估生长，在6.5或12个月时评估缺铁性贫血。母亲在怀孕期间酗酒（每次4杯）的婴儿在12个月时被诊断为缺铁性贫血的可能性是母亲不酗酒的婴儿的3.6倍。产前酒精暴露与出生、6.5个月和12个月时体重减轻有关，与6.5个月和12个月时体重减少有关。缺铁性贫血与12个月体重和头围降低以及6 ~ 12个月生长速度减慢有关。产前酒精对体重的影响与缺铁性贫血无关；然而，它们主要见于缺铁性贫血的婴儿。母亲暴饮与缺铁性贫血发病率增加的关联可能反映了胎儿铁储存积累的中断或出生后铁摄取、吸收或摄入的不足。此外，缺铁似乎加剧了产前酒精对生长的影响。
OBJECTIVES. Our goals were to determine whether prenatal alcohol exposure is associated with an increased incidence of iron-deficiency anemia in infancy and to compare effects of fetal alcohol exposure and iron-deficiency anemia on infant growth. We also tested whether effects of fetal alcohol exposure on growth are mediated or moderated by iron-deficiency anemia.METHODS. A total of 96 infants born to mothers from the Coloured ( mixed ancestry) community in Cape Town, South Africa, were recruited prenatally; 42 mothers drank heavily during pregnancy, and 54 abstained or drank small amounts of alcohol. Growth was assessed at birth and 6.5 and 12 months, and iron-deficiency anemia was assessed at 6.5 or 12 months.RESULTS. Infants whose mothers binge drank during pregnancy ( >= 4 drinks per occasion) were 3.6 times more likely to be diagnosed with iron-deficiency anemia at 12 months than were infants whose mothers did not binge drink. Prenatal alcohol exposure was associated with reduced weight at birth, 6.5 months, and 12 months and with shorter length at 6.5 and 12 months. Iron-deficiency anemia was related to reduced 12-month weight and head circumference and to slower growth velocity between 6 and 12 months. The effects of prenatal alcohol on weight were not mediated by iron-deficiency anemia; however, they were seen primarily in infants with iron-deficiency anemia.CONCLUSIONS. The association of maternal binge drinking with an increased incidence of iron-deficiency anemia may reflect disruption of accumulation of fetal iron stores or postnatal deficiencies in iron uptake, absorption, or intake. Moreover, iron deficiency seems to exacerbate the prenatal alcohol effects on growth.