Inhibition of gastric acid secretion by intracerebral injection of calcitonin gene related peptide in rats.
Inhibition of gastric acid secretion by intracerebral injection of calcitonin gene related peptide in rats.
复制标题
脑内注射降钙素基因相关肽抑制大鼠胃酸分泌。
DOI：
10.1016/0024-3205(84)90413-2
复制
发表时间：
1984
期刊：
影响因子：
6.1
通讯作者：
Goto,Y
中科院分区：
文献类型：
--
作者：
Taché,Y;Gunion,M;Lauffenberger,M;Goto,Y
降钙素基因相关肽（CGRP），一个37个氨基酸的肽最近从大鼠脑中的特点，注入小脑延髓池或外侧下丘脑，抑制胃酸分泌，并增加清醒幽门结扎大鼠血清胃泌素水平。降钙素基因相关肽抑制五肽胃泌素和组胺诱导的刺激胃分泌在胃窦麻醉胃瘘大鼠。肽的作用是剂量依赖性的，不修改肾上腺切除术和外周交感神经切除术引起的乙啶预处理和迷走神经切断术逆转。这些结果表明，脑池内或侧下丘脑内注射CGRP抑制刺激的胃酸分泌。作用机制是迷走神经依赖性的，与胃泌素分泌的改变或交感神经流出的激活无关。
Calcitonin gene related peptide (CGRP), a 37 amino acid peptide recently characterized from the rat brain, injected into the cisterna magna or the lateral hypothalamus, inhibited gastric acid secretion and increased serum gastrin levels in conscious pylorus-ligated rats. CGRP suppressed pentagastrin- and histamine-induced stimulation of gastric secretion in urethane-anesthetized gastric fistula rats. Peptide action was dose-dependent, not modified by adrenalectomy and peripheral sympathectomy induced by guanethidine pretreatment and reversed by vagotomy. These results demonstrate that intraceisternal or intralateral hypothalamic injection of CGRP inhibits stimulated gastric acid secretion. The mechanism of action is vagal dependent and unrelated to modification of gastrin secretion or activation of sympathetic outflow.