Bone metastasis from glioblastoma: a systematic review.
Bone metastasis from glioblastoma: a systematic review.
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胶质母细胞瘤骨转移：系统评价。
DOI：
10.1007/s11060-022-04025-4
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发表时间：
2022
影响因子：
3.9
通讯作者：
Szerlip,Nichola
中科院分区：
文献类型：
--
作者：
Strong,MichaelJ;Koduri,Sravanthi;Allison,JodiA;Pesavento,CeciliaM;Ogunsola,Sebele;Ogunsola,Oludotun;Yee,TimothyJ;Khalsa,SiriSahibS;Saadeh,YamaanS;Joseph,JacobR;Kashlan,OsamaN;Park,Paul;Oppenlander,MarkE;Szerlip,Nichola
胶质母细胞瘤(Glioblastoma，GBM)是一种总存活率较低的破坏性疾病。尽管基底膜在原发脑肿瘤中很常见，但转移性疾病很少见。我们的目标是对有骨转移的GBM进行系统的文献综述，了解脊柱相对于骨骼其余部分的转移率，以及这种组织学如何适应我们目前治疗骨转移的范例。方法使用PubMed数据库进行1952年至2021年符合系统综述和荟萃分析(PRISMA)的首选报告项目的文献搜索。检索词“GBM”、“胶质母细胞瘤”、“高级别胶质瘤”、“骨转移”和“骨转移”。结果在最初确定的659篇研究中，67篇纳入本综述。在这67篇文章中，共有92例不同的胶质母细胞瘤转移到骨的病例表现被确认。在这些病例中，58例(63%)累及脊柱，其余累及颅骨、胸骨、肋骨和附件骨的病变。虽然真正的发病率尚不清楚，但对于有症状的患者，有必要对转移性疾病，特别是涉及脊柱的疾病进行检查。最后，GBM脊柱转移患者的治疗可以遵循国际脊柱肿瘤协会的两步多学科算法来管理脊柱转移。
IntroductionGlioblastoma (GBM) is a devastating disease with poor overall survival. Despite the common occurrence of GBM among primary brain tumors, metastatic disease is rare. Our goal was to perform a systematic literature review on GBM with osseous metastases and understand the rate of metastasis to the vertebral column as compared to the remainder of the skeleton, and how this histology would fit into our current paradigm of treatment for bone metastases.MethodsA Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compliant literature search was performed using the PubMed database from 1952 to 2021. Search terms included “GBM”, “glioblastoma”, “high-grade glioma”, “bone metastasis”, and “bone metastases”.ResultsOf 659 studies initially identified, 67 articles were included in the current review. From these 67 articles, a total of 92 distinct patient case presentations of metastatic glioblastoma to bone were identified. Of these cases, 58 (63%) involved the vertebral column while the remainder involved lesions within the skull, sternum, rib cage, and appendicular skeleton.ConclusionMetastatic dissemination of GBM to bone occurs. While the true incidence is unknown, workup for metastatic disease, especially involving the spinal column, is warranted in symptomatic patients. Lastly, management of patients with GBM vertebral column metastases can follow the International Spine Oncology Consortium two-step multidisciplinary algorithm for the management of spinal metastases.