Multiple roles of Arabidopsis VRN1 in vernalization and flowering time control
Multiple roles of Arabidopsis VRN1 in vernalization and flowering time control
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DOI：
10.1126/science.1072147
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发表时间：
2002-07-12
期刊：
影响因子：
56.9
通讯作者：
Dean, C
中科院分区：
文献类型：
--
作者：
Levy, YY;Mesnage, S;Dean, C
拟南芥VRN基因介导春化作用，通过该过程，长时间的寒冷诱导有丝分裂稳定状态，导致在后期发育期间加速开花。VRN1编码一种蛋白质，该蛋白质在体外以非序列特异性方式结合DNA，并在稳定抑制春化途径的主要靶点（口腔阻遏物FLC）中发挥作用。VRN1的过表达揭示了VRN1的春化独立功能，主要通过口腔途径整合剂FT介导，并表明VRN1需要春化特异性因子来靶向FLC。
Arabidopsis VRN genes mediate vernalization, the process by which a long period of cold induces a mitotically stable state that leads to accelerated flowering during later development. VRN1 encodes a protein that binds DNA in vitro in a non sequence-specific manner and functions in stable repression of the major target of the vernalization pathway, the oral repressor FLC. Overexpression of VRN1 reveals a vernalization-independent function for VRN1, mediated predominantly through the oral pathway integrator FT, and demonstrates that VRN1 requires vernalization-specific factors to target FLC.