Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome
Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome
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DOI：
10.1210/jc.81.11.4166
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发表时间：
1996-11-01
影响因子：
5.8
通讯作者：
Magoffin, DA
中科院分区：
文献类型：
--
作者：
Brzechffa, PR;Jakimiuk, AJ;Magoffin, DA
最近在老鼠身上的数据表明，瘦素是一种由脂肪细胞产生的蛋白质激素，是生育所必需的。在缺乏瘦素的情况下，小鼠变得肥胖、糖尿病和不育。多囊卵巢综合征（PCOS）是女性不孕的常见原因，与肥胖和胰岛素抵抗有关。由于肥胖妇女多囊卵巢综合征的发病率增加，我们检验了血清瘦素浓度的改变可能与多囊卵巢综合征有关的假设。对58例PCOS患者和70例正常月经妇女（对照组）进行了瘦素免疫反应性测定。如前所述，瘦素水平与体重指数（BMI）呈正相关。虽然大多数PCOS妇女的瘦素水平在对照范围内，但29%的PCOS妇女的瘦素水平高于BMI的99%预测区间，没有一个瘦素水平低。对照组妇女瘦素水平与游离睾酮和胰岛素敏感性呈正相关。在PCOS患者中，13%和9.5%的患者在游离睾酮和胰岛素敏感性方面的瘦素浓度分别高于预期。胰岛素抵抗的PCOS妇女瘦素水平高于对照组。数据表明，相当大比例的PCOS女性的瘦素水平高于其BMI，游离睾酮和胰岛素敏感性的预期水平。这些结果表明，瘦素信号传导到生殖系统的异常可能涉及某些情况下的PCOS。
Recent data in the mouse demonstrate that leptin, a protein hormone produced by fat cells, is required for fertility. In the absence of leptin the mice become obese, diabetic and infertile. Polycystic ovary syndrome (PCOS), a common cause of infertility in women, is associated with obesity and insulin resistance. Because of the increased frequency of PCOS in obese women we tested the hypothesis that alterations in serum leptin concentrations might be associated with PCOS. Immunoreactive leptin concentrations were measured in 58 women with PCOS and 70 regularly menstruating (control) women. As has previously been shown there nias a positive correlation between leptin levels and body mass index (BMI). Although the leptin levels in the majority of women with PCOS fell within the control range, 29% of PCOS women had leptin levels above the 99% prediction interval for their BMI and none had low leptin levels. There were also positive correlations of leptin levels with free testosterone and insulin sensitivity in control women. In women with PCOS, 13% and 9.5% exhibited higher than expected leptin concentrations with respect to free testosterone and insulin sensitivity, respectively. Insulin resistant PCOS women had higher leptin levels than controls. The data demonstrate that a substantial proportion of women with PCOS have leptin levels that are higher than expected for their BMI, free testosterone and insulin sensitivity. These results suggest that abnormalities in leptin signaling to the reproductive system may be involved in certain cases of PCOS.