ISOLATION OF A NEW HUMAN RETROVIRUS FROM WEST-AFRICAN PATIENTS WITH AIDS
ISOLATION OF A NEW HUMAN RETROVIRUS FROM WEST-AFRICAN PATIENTS WITH AIDS
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DOI：
10.1126/science.2425430
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发表时间：
1986-07-18
期刊：
影响因子：
56.9
通讯作者：
MONTAGNIER, L
中科院分区：
文献类型：
--
作者：
CLAVEL, F;GUETARD, D;MONTAGNIER, L
艾滋病的病原体LAV/HTLV-III在中非很常见，但在该大陆的其他地区并不流行。一种不同于LAV/HTLV-III的新型人类逆转录病毒现已从西非的两名艾滋病患者中分离出来。该病毒的部分特征表明，它具有与LAV非常相似的生物学和形态学特性，但在某些抗原成分上不同。虽然核心抗原可能共享一些共同的表位，西非艾滋病逆转录病毒和LAV在其包膜糖蛋白上有很大的不同。西非病毒的包膜抗原可被感染猴逆转录病毒（称为STLV-IIImac）的猴艾滋病猕猴的血清识别，这表明西非艾滋病病毒可能与这种猴病毒的关系比LAV更密切。与LAV亚基因组探针的杂交实验进一步确定了这种新的逆转录病毒，这里称为LAV-II，与LAV远亲，与STLV-IIImac不同。
The etiological agent of AIDS, LAV/HTLV-III, is common in Central Africa but is not endemic in other areas of that continent. A novel human retrovirus, distinct from LAV/HTLV-III, has now been isolated from two AIDS patients from West Africa. Partial characterization of this virus revealed that it has biological and morphological properties very similar to LAV but that it differs in some of its antigenic components. Although the core antigens may share some common epitopes, the West African AIDS retrovirus and LAV differ substantially in their envelope glycoproteins. The envelope antigen of the West African virus can be recognized by serum from a macaque with simian AIDS infected by the simian retrovirus termed STLV-IIImac, suggesting that the West African AIDS virus may be more closely related to this simian virus than to LAV. Hybridization experiments with LAV subgenomic probes further established that this new retrovirus, here referred to as LAV-II, is distantly related to LAV and distinct from STLV-IIImac.