The Spanish Lung Transplant Registry: First Report of Results (2006-2010)
The Spanish Lung Transplant Registry: First Report of Results (2006-2010)
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DOI：
10.1016/j.arbres.2012.06.001
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发表时间：
2013-02-01
影响因子：
8
通讯作者：
Roman, Antonio
中科院分区：
文献类型：
--
作者：
Coll, Elisabeth;Santos, Francisco;Roman, Antonio
西班牙肺移植登记处（SLTR）于2006年开始活动，所有在西班牙开展活动的肺移植（LT）团体都参与其中。本报告首次介绍了2006年至2010年在西班牙接受肺移植的患者的总体描述和结果。LT活性逐渐增加，在此期间，951名成人和31名儿童接受了肺移植。受体的平均年龄为48.2岁，而肺供体的平均年龄为41.7岁。在成人LT中，肺移植最常见的原因是肺气肿/COPD，其次是特发性肺纤维化，两者均占适应症总数的60%以上。成人移植后1年和3年的生存率分别为72%和60%，尽管在移植后3个月存活的患者中，这些存活率达到89.7%和75.2%。最明显影响患者存活的因素是受体的年龄和表明移植的诊断。在儿科移植中，囊性纤维化是移植的主要原因（68%），一年生存率为80%，三年生存率为70%。在成人和儿童移植中，最常见的死亡原因是感染。这些数据证实了LT在西班牙作为晚期慢性呼吸道疾病治疗选择的综合情况，无论是儿童还是成人。(C)2012年SEPAR。出版社：Elsevier Espana，S.L. All rights reserved.
The Spanish Lung Transplant Registry (SLTR) began its activities in 2006 with the participation of all the lung transplantation (LT) groups with active programs in Spain. This report presents for the first time an overall description and results of the patients who received lung transplants in Spain from 2006 to 2010. LT activity has grown progressively, and in this time period 951 adults and 31 children underwent lung transplantation. The mean age of the recipients was 48.2, while the mean age among the lung donors was 41.7. In adult LT, the most frequent cause for lung transplantation was emphysema/COPD, followed by idiopathic pulmonary fibrosis, both representing more than 60% the total number of indications. The probability for survival after adult LT to one and three years was 72% and 60%, respectively, although in patients who survived until the third month post-transplantation, these survival rates reached 89.7% and 75.2%. The factors that most clearly influenced patient survival were the age of the recipient and the diagnosis that indicated the transplantation. Among the pediatric transplantations, cystic fibrosis was the main cause for transplantation (68%), with a one-year survival of 80% and a three-year survival of 70%. In adult as well as pediatric transplantations, the most frequent cause of death was infection.These data confirm the consolidated situation of LT in Spain as a therapeutic option for advanced chronic respiratory disease, both in children as well as in adults. (C) 2012 SEPAR. Published by Elsevier Espana, S.L. All rights reserved.