Merging complexes: properties of membrane raft assembly during lymphocyte signaling.
Merging complexes: properties of membrane raft assembly during lymphocyte signaling.
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DOI：
10.1016/j.it.2004.11.016
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发表时间：
2005-02
影响因子：
16.8
通讯作者：
W. Rodgers;Darise Farris;Sudha Mishra
中科院分区：
文献类型：
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作者：
W. Rodgers;Darise Farris;Sudha Mishra
在脂筏模型中，细胞膜含有抗洗涤剂的膜结构域或筏，其在细胞信号传导中起作用。最近的研究结果表明，筏组装形成直径为微米的宏域，其中一个例子是刺激淋巴细胞中的免疫突触。由于免疫突触是淋巴细胞活化所必需的，因此破译其组装机制一直是一个活跃的研究课题。目前的模型，其中宏域的形成和维护，通过关联筏与肌动蛋白细胞骨架，在这里进行了讨论。最近提出了支持或挑战该模型的证据，以及表明宏域组装可能充当淋巴细胞信号传导和功能守门人的数据。
In the lipid raft model, cell membranes contain detergent-resistant membrane domains, or rafts, that function in cell signaling. Recent findings have shown rafts are assembled to form macrodomains that are micrometers in diameter, one example of which is the immune synapse in stimulated lymphocytes. Because immune synapses are necessary for lymphocyte activation, deciphering the mechanism of their assembly has been an active topic of research. A current model, in which macrodomains are formed and maintained through association of rafts with the actin cytoskeleton, is discussed here. Recent evidence that either supports or challenges this model is presented, as well as data suggesting that macrodomain assembly might act as a gatekeeper to lymphocyte signaling and functioning.